Synthesis, Spectroscopic Characterization and Antibacterial Activity of Organotin(IV) Complexes Containing Hydrazone Ligand: X-ray Single Crystal Structure of [<i>n</i>-Bu<sub>2</sub>Sn(H<sub>2</sub>PAI).H<sub>2</sub>O]

Authors

  • M. A. Affan Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
  • B. A. Fasihuddin Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
  • Y. Z. Liew Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
  • S. W. Foo Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
  • J. Ismail Department of Plant Science, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Malaysia

DOI:

https://doi.org/10.3329/jsr.v1i2.1775

Keywords:

Organotin(IV) complexes, Hydrazone ligand, Spectral studies, Crystal structure, Antibacterial activity.

Abstract

Five new organotin(IV) complexes with pyruvic acid isonicotinoyl hydrazone [H4PAI (1)] of the general formula [Me2Sn(H2PAI)] (2), [R2Sn(H2PAI).H2O] [R=n-Bu, (3) or Ph, (4)], [RSnCl(H2PAI).H2O] [R=Me (5) or Ph (6)] have been synthesized in the presence of base in absolute methanol in 1:2:1 mole ratio (metal:base:ligand). All organotin(IV) complexes are characterized by elemental analyses, molar conductance values, UV-Visible, IR and 1H NMR spectral studies. The crystal structure of organotin(IV) complex (3) has also been determined by X-ray crystallography diffraction analyses. Complex [n-Bu2Sn(H2PAI).H2O] (3) is orthorhombic with space group P2(1)/c with a=27.517(5), b=9.6574(18), c=15.742(3) Å, α=90°, β=90°, γ=90°, V=4183.4(13) Å3, Z=8 and Dcalc=1.448 mg m-3. The complex [n-Bu2Sn(H2PAI).H2O] (3) shows a distorted octahedral geometry with coordination for the central tin(IV) atom and exhibits two monomeric structures in one unit cell. In the complex (3), the pyruvic acid isonicotinoyl hydrazone ligand is coordinated to the tin(IV) as dinegative tridentate chelating agent via the carboxylic-O, enolic-O and imine-N atoms. Hydrazone ligand (1) and its organotin(IV) complexes have also been screened for their antimicrobial activities and found to be relatively active.

Keywords: Organotin(IV) complexes; Hydrazone ligand; Spectral studies; Crystal structure; Antibacterial activity.

© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

DOI: 10.3329/jsr.v1i2.1775

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Author Biographies

M. A. Affan, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

M.A. Affan

Deptartment of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia


B. A. Fasihuddin, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

B. A. Fasihuddin

Deptartment of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

 

Y. Z. Liew, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

Y. Z. Liew

Deptartment of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

S. W. Foo, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

S. W. Foo

 

Deptartment of Chemistry, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia


J. Ismail, Department of Plant Science, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Malaysia

J. Ismail


Department of Plant Science, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia

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Published

2009-04-23

How to Cite

Affan, M. A., Fasihuddin, B. A., Liew, Y. Z., Foo, S. W., & Ismail, J. (2009). Synthesis, Spectroscopic Characterization and Antibacterial Activity of Organotin(IV) Complexes Containing Hydrazone Ligand: X-ray Single Crystal Structure of [<i>n</i>-Bu<sub>2</sub>Sn(H<sub>2</sub>PAI).H<sub>2</sub>O]. Journal of Scientific Research, 1(2), 306–316. https://doi.org/10.3329/jsr.v1i2.1775

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Section

Section B: Chemical and Biological Sciences