Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

Authors

  • E. H. Ismail Taibah University as temporary Ain Shams Univesity as permenant
  • D. Y. Sabry Ain Shams University
  • H. Mahdy Ain Shams University, Cairo
  • M. M. H. Khalil Ain Shams University, Cairo

DOI:

https://doi.org/10.3329/jsr.v6i3.18750

Keywords:

Uv-vis spectrum, Biological activity, Hepatocellular carcinoma

Abstract

Some ternary complexes of curcumin have been synthesized by the reaction of M(II) nitrate with curcumin as primary ligand and 1,10-phenanthroline (phen) as supporting ligand in water/ethanol solution under a nitrogen atmosphere. The composition of the complexes has been characterized by elemental analysis, molar conductivity, thermogravimetric analysis, IR, UVvis spectroscopy. The results reveal that curcumin ligand coordinates with M(II) in bidentate mode after deprotonation. The supporting ligand (phen) uses its two N atoms in coordination with metal ions in bidentate mode. The general formula of the complexes is [M(Cur)(phen)]NO3 (M = Ni(II), Co(II), Cu(II) and Z(II)). The results of antibacterial activity indicated that the complexes have good antibacterial ability for the testing bacterium than that of curcumin. Furthermore, the [M(Cur)(phen)]NO3 complexes were evaluated for its in vitro anticancer activity against hepatocellular carcinoma.

© 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v6i3.18750 J. Sci. Res. 6 (3), 509-519 (2014)

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Author Biographies

E. H. Ismail, Taibah University as temporary Ain Shams Univesity as permenant

Chemistry Department

Associat Prof.

D. Y. Sabry, Ain Shams University

Chemistry Department, Faculty of Science, Ain Shams University, Cairo

H. Mahdy, Ain Shams University, Cairo

Chemistry Department, Faculty of Science, Ain Shams University, Cairo

M. M. H. Khalil, Ain Shams University, Cairo

Chemistry Department, Faculty of Science, Ain Shams University, Cairo

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Published

2014-08-26

How to Cite

Ismail, E. H., Sabry, D. Y., Mahdy, H., & Khalil, M. M. H. (2014). Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications. Journal of Scientific Research, 6(3), 509–519. https://doi.org/10.3329/jsr.v6i3.18750

Issue

Vol. 6 No. 3 (2014)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

Creative Commons License

Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.