Bioequivalence Assessment of Metformin Tablet Formulations of Bangladesh

Authors

  • M. A. Islam Square Pharmaceuticals Ltd, Salgaria, Pabna,
  • A. Islam Department of Pharmacy, University of Rajshahi,
  • M. R. I. Khan Department of Pharmacy, University of Rajshahi
  • R. Sharmin Department of Pharmacy, Jessore University of Science and Technology, Jessore-7408,
  • M. I. I. Wahed Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • A. S. M Anisuzzaman Department of Pharmacy, University of Rajshahi, Rajshahi-6205

DOI:

https://doi.org/10.3329/jsr.v6i3.19290

Keywords:

Metformin, oral hypoglycemic agent, Streptozotocin-induced diabetic rats.

Abstract

Six marketed oral antidiabetic metformin tablets in Bangladesh have been studied for their drug content, release profile and glucose lowering capacities. This sort of study is a good indicator for in vivo evaluation of the quality of an oral antidiabetic preparation. Marketed preparations of metformin-HCl from different manufacturers were randomly chosen for this study. The drug content was within the United State Pharmacopoeia (USP) specified limit (95-105%) in all cases. The blood glucose levels were investigated in streptozotocin-induced diabetic rats (SIDRs) after 5 hours of single dose (110 mg/kg body weight) treatment of the products; significantly (p<0.05) reduced blood glucose level by 58.1, 53.2, 50.8, 77.0, 72.9 and 49.1%, respectively; which were consistent with antihyperglycemic effects of standard metformin-HCl (71.3%). All the products were found to be qualified in lowering blood glucose level. It may be inferred that the metformin-HCl tablets of Bangladeshi manufacturers complies with the standard specifications for drug contents, dissolution and antihyperglycemic properties.

© 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v6i3.19290 J. Sci. Res. 6 (3), 581-588 (2014)

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Published

2014-08-26

How to Cite

Islam, M. A., Islam, A., Khan, M. R. I., Sharmin, R., Wahed, M. I. I., & Anisuzzaman, A. S. M. (2014). Bioequivalence Assessment of Metformin Tablet Formulations of Bangladesh. Journal of Scientific Research, 6(3), 581–588. https://doi.org/10.3329/jsr.v6i3.19290

Issue

Vol. 6 No. 3 (2014)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

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