Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives

Authors

  • M. I. Hossain Department of Chemistry, University of Chittagong
  • M. M. H. Bhuiyan Department of Chemistry, University of Chittagong

DOI:

https://doi.org/10.3329/jsr.v1i2.2299

Keywords:

Fused pyrimidines, Hydrazino compound, Thienotriazolopyrmidines, Thienopyrimidines, Antimicrobial activity.

Abstract

Fused pyrimidines, 8,9-dimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 5, 3,8,9-trimethyl[1,2,4]triazolo[4,3-c]thieno[3,2-e]pyrimidine 6, 4-benzylidinehydrazono-5,6  dimethylthieno[2,3-d]pyrimidine 7, 4-[4/-hydroxybenzylidine]hydrazono-5,6-dimethylthi-eno[2,3-d]pyrimidine 8, 4-[4/-tolylidin]hydrazono-5,6-dimethylthieno[2,3-d]pyrimidine 9, 4-[4/-nitrobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 10 and 4-[4/-chlorobenzylidine]hydrazono-5-ethyl-6-methylthieno[2,3-d]pyrimidine 11 are prepared in good yield by an initial treatment of 2-amino-4,5-dimethylthiophene-3-carbonitrile 1 with formic acid, affording 5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one 2, which is chlorinated with thionyl chloride and then hydrazinated with hydrazine hydrate. Finally hydrazino compound 4 is reacted with formic acid, acetic anhydrate, benzaldehyde, p-hydroxybenzaldehyde, p-toluayldehyde, p-nitrobenzaldehyde and p-chlorobenzaldehyde to give thienotriazolopyrimidines 5-6 and thienopyrimidines 7-11 respectively. All the compounds have been screened for their antimicrobial activity.

 

Keywords: Fused pyrimidines; Hydrazino compound; Thienotriazolopyrmidines; Thienopyrimidines; Antimicrobial activity.


© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights

reserved.


DOI: 10.3329/jsr.v1i2.2299


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Author Biographies

M. I. Hossain, Department of Chemistry, University of Chittagong

Assistant Professor

Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh



M. M. H. Bhuiyan, Department of Chemistry, University of Chittagong


ProfessorDepartment of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh



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Published

2009-04-23

How to Cite

Hossain, M. I., & Bhuiyan, M. M. H. (2009). Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives. Journal of Scientific Research, 1(2), 317–325. https://doi.org/10.3329/jsr.v1i2.2299

Issue

Section

Section B: Chemical and Biological Sciences