Role of Mathematical Modeling in Controlled Drug Delivery

Authors

  • Moharram A. Khan Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi
  • Shafeeq. T Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi

DOI:

https://doi.org/10.3329/jsr.v1i3.2581

Keywords:

Controlled drug delivery, Diffusion, Doxorubicin, Mathematical Modeling, Release Kinetics.

Abstract

Controlled drug delivery occurs when a polymer or lipid (natural or synthetic) is judiciously combined with a drug or other active agent in such a way that the active agent is released from the material in a pre-designed manner. The aim of controlling the drug delivery is to achieve more effective therapies while eliminating potential for both under- and overdosing. Controlled delivery systems includes the maintenance of drug levels within a desired range, the need for fewer administrations, optimal use of the drug in question, and increased patient compliance. Mathematical modeling of controlled drug delivery can help to provide a scientific knowledge base concerning the mass transport mechanisms that are involved in the control of drug release. Mathematically, it is identified for designing a particular pharmaceutical system and it can be used to simulate the effect of the device design parameters (viz., geometry and composition) on the resulting drug release kinetics. The objective of this review outlines the application of mathematical modeling to the controlled drug delivery mechanisms, focusing particular attention on drug transport in human breast cancer, treated with the drug Doxorubicin. 

Keywords: Controlled drug delivery; Diffusion; Doxorubicin; Mathematical Modeling; Release Kinetics.

© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

DOI: 10.3329/jsr.v1i3.2581              J. Sci. Res. 1 (3), 539-550 (2009)

 

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Author Biographies

Moharram A. Khan, Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi

Moharram A. Khan

Centre for Interdisciplinary Research in Basic Sciences (CIRBSc)

Jamia Millia Islamia, Jamia Nagar, New Delhi-110025

 

 

 

Shafeeq. T, Centre for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia, New Delhi

Shefeeq. T

Centre for Interdisciplinary Research in Basic Sciences (CIRBSc)

Jamia Millia Islamia, Jamia Nagar, New Delhi-110025

 

 

 

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Published

2009-08-29

How to Cite

Khan, M. A., & T, S. (2009). Role of Mathematical Modeling in Controlled Drug Delivery. Journal of Scientific Research, 1(3), 539–550. https://doi.org/10.3329/jsr.v1i3.2581

Issue

Section

Section A: Physical and Mathematical Sciences