Protective Effect of <i>Alpina nigra</i> Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride

Authors

  • A. M. T. Islam
  • M. A. U. Chowdhury
  • M. E. Uddin
  • M. R. Islam
  • F. Sharmen
  • M. S. Parvin
  • M. E. Islam rajshahi university

DOI:

https://doi.org/10.3329/jsr.v8i3.26842

Keywords:

Methanol extract, Hepatotoxicity, CCl4, Leaves.

Abstract

The present study was aimed to evaluate the hepatoprotective activity of methanol extract against carbon tetrachloride (CCl4) induced hepatic damage in rats. CCl4 caused liver damage in rats manifested by significant rise in serum enzyme levels. To examine the effect of the extract male albino rats were used and extract was administered orally at a dose of 300 mg/kg once daily. The results obtained showed that there were reductions in the activities of serum SGOT, SGPT, ALP, total protein, total bilirubin from 97.67±1.78, 275.67±2.86, 934 ± 1.41, 1.13±0.227 and 7.50±0.707 in animals treated with toxic doses of CCl4 to 78.33±1.08, 53±1.41, 870±0.707, 0.67±0.04 and 6.47±0.356 in animal treated with extract before CCl4 intoxication. The extract could also repair the abnormal lipid profile. From these results, it is concluded that methanol extract of Alpina nigra leaves has hepatoprotective activity in CCl4-induced hepatic damage in rats.



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Author Biography

M. E. Islam, rajshahi university

Associate Professor

Dept. of Pharmacy

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Published

2016-09-01

How to Cite

Islam, A. M. T., Chowdhury, M. A. U., Uddin, M. E., Islam, M. R., Sharmen, F., Parvin, M. S., & Islam, M. E. (2016). Protective Effect of <i>Alpina nigra</i> Leaves Extract in Mouse Liver Injury Induced by Carbon Tetrachloride. Journal of Scientific Research, 8(3), 381–386. https://doi.org/10.3329/jsr.v8i3.26842

Issue

Vol. 8 No. 3 (2016)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

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Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.