Characterization and Antimicrobial Activities of a Metabolite from a New <i>Streptomyces</i> Species from Bangladeshi Soil

Authors

  • M. Akhand Pharmacy Department
  • M. A. A. Al-Bari Pharmacy Department
  • M. A. Islam Pharmacy Department
  • Proma Khondkar Pharmacy Department

DOI:

https://doi.org/10.3329/jsr.v2i1.3079

Keywords:

Streptomyces, Aantimicrobial activity, Cytotoxicity.

Abstract

A new actinomycete strain was isolated from Western part of Bangladesh and identified as a new Streptomyces species on the basis of its morphological, biochemical, cultural characteristics and 16S rRNA data. The present paper describes the isolation and characterization of compound 1 from this new Streptomyces species with the help of various chemical and spectroscopic methods. Antimicrobial activity of compound 1 was tested by disc diffusion assay method and compared with that of standard antibiotics (Kanamycin for antibacterial activity and Nystatin for antifungal activity). The compound has been found to exhibit moderate to strong antimicrobial activity against the test organisms. Cytotoxicity of the compound 1 and the pet. ether extract of Czapek Dox (alkaline) broth of Streptomyces species was evaluated in brine shrimp bioassay with LC50 values of 23.85 µg/ml (ppm) and 19.95 µg/ml (ppm), respectively.

 

Keywords: Streptomyces; Antimicrobial activity; Cytotoxicity.

 

© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

DOI: 10.3329/jsr.v2i1.3079                  J. Sci. Res. 2 (1), 178-185 (2010)

 

 

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Author Biographies

M. Akhand, Pharmacy Department

Department of Pharmacy

Research Student

M. A. A. Al-Bari, Pharmacy Department

Department of Pharmacy

Assistant Professor

M. A. Islam, Pharmacy Department

Department of Pharmacy

Professor

Proma Khondkar, Pharmacy Department

Department of Pharmacy

Associate Professor

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Published

2009-12-29

How to Cite

Akhand, M., Al-Bari, M. A. A., Islam, M. A., & Khondkar, P. (2009). Characterization and Antimicrobial Activities of a Metabolite from a New <i>Streptomyces</i> Species from Bangladeshi Soil. Journal of Scientific Research, 2(1), 178–185. https://doi.org/10.3329/jsr.v2i1.3079

Issue

Section

Section B: Chemical and Biological Sciences