Synthesis and Antimicrobial Activity of 7-Hydroxy-3',4'-Methylenedioxy- and 7-Benzyloxy-3',4'-Methylenedioxy Flavanones

Authors

  • R. Ali Dept. of Chemistry, University of Rajshahi
  • A. Rahim
  • A. Islam

DOI:

https://doi.org/10.3329/jsr.v9i3.31229

Keywords:

Aldol reaction, Chalcone, Flavanone, Antibacterial activity, Antifungal activity.

Abstract

7-Hydroxy-3',4'-methylenedioxy- and 7-benzyloxy-3',4'-methylenedioxy flavanones have been synthesized starting from 2,4-dihydroxyacetophenone. Subsequently biocidal activities of the flavanones have been investigated along with their corresponding chalcones against some bacterial and fungal strains. 2'-Hydroxy-4'-benzyloxy-3,4-methylenedioxy chalcone (5) and its corresponding flavanone (7) showed good antibacterial and antifungal activities against some selected bacterial and fungal strains. On the other hand, 2',4'-dihydroxy-3,4-methylenedioxy chalcone (4) showed no antibacterial and antifungal activities while its corresponding flavanone (6) showed a little antibacterial activity only at higher concentration but did not show antifungal activity. The synthesized chalcones and flavanones have been characterized using UV-Vis, IR and 1H NMRspectral data together with elemental analysis.

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Published

2017-09-01

How to Cite

Ali, R., Rahim, A., & Islam, A. (2017). Synthesis and Antimicrobial Activity of 7-Hydroxy-3’,4’-Methylenedioxy- and 7-Benzyloxy-3’,4’-Methylenedioxy Flavanones. Journal of Scientific Research, 9(3), 297–306. https://doi.org/10.3329/jsr.v9i3.31229

Issue

Section

Section B: Chemical and Biological Sciences