Microwave-assisted Efficient Synthesis of Isatins and <i>spiro</i>-Thiadiazolines under Green Chemistry Protocol
DOI:
https://doi.org/10.3329/jsr.v2i2.3731Keywords:
Microwave-synthesis, Isatins, Schiff-base, spiro-Thiadiazoline, Green chemistry.Abstract
MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield.
Keywords: Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry.
© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.
DOI: 10.3329/jsr.v2i2.3731 J. Sci. Res. 2 (2), 322-329 (2010)
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