Microwave-assisted Efficient Synthesis of Isatins and <i>spiro</i>-Thiadiazolines under Green Chemistry Protocol

Authors

  • M. M. Hossain Jahangirnagar university
  • M. A. Foysal Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
  • M. Mahabub Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh
  • Al- Amin Department of Synthetic Chemistry, Shoumachi, Tokushima University, 770-8505, Japan

DOI:

https://doi.org/10.3329/jsr.v2i2.3731

Keywords:

Microwave-synthesis, Isatins, Schiff-base, spiro-Thiadiazoline, Green chemistry.

Abstract

MW-assisted treatment of oximinoacetanilides obtained from substituted primary aromatic amines was carried out in conc. H2SO4 medium for 5-10 sec to give cyclic amides (isatins) through intramolecular cyclization by means of electrophilic aromatic substitution. Isatins reacted with thiosemicarbazide under MW-condition gave the corresponding Schiff-bases. The Schiff-bases undergo cyclization in presence of minimal Ac2O under MW-irradiation for 3-4 min to give the spiro-thiadiazoline acetyl derivatives in excellent yield.

 

Keywords:  Microwave-synthesis; Isatins; Schiff-base; spiro-Thiadiazoline; Green chemistry.

 

© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 

 DOI: 10.3329/jsr.v2i2.3731               J. Sci. Res. 2 (2), 322-329 (2010)

 

 

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Author Biographies

M. M. Hossain, Jahangirnagar university

Department of Chemistry

Associate Professor

M. A. Foysal, Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

M. A. Foysal 

Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

 

 

chemalamin1@yahoo.com

mahabub_shovon@yahoo.com

foysal_aziz@yahoo.com
 

M. Mahabub, Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

M. Mahabub

Department of Chemistry, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

 

Al- Amin, Department of Synthetic Chemistry, Shoumachi, Tokushima University, 770-8505, Japan

Al-Amin

 

 

Department of Synthetic Chemistry, Shoumachi, Tokushima University, 770-8505, Japan

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Published

2010-04-26

How to Cite

Hossain, M. M., Foysal, M. A., Mahabub, M., & Amin, A.-. (2010). Microwave-assisted Efficient Synthesis of Isatins and <i>spiro</i>-Thiadiazolines under Green Chemistry Protocol. Journal of Scientific Research, 2(2), 322–329. https://doi.org/10.3329/jsr.v2i2.3731

Issue

Vol. 2 No. 2 (2010)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

Creative Commons License

Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.