Formulation, Development and Evaluation of Bisoprolol Sustained Release Tablets

Authors

  • M. Masum Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
  • M. A. R. Ripon Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
  • D. R. Bhowmik Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
  • M. T. Amin Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh
  • S. Arefin Department of Pharmacy, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh
  • M. S. Hossain Department of Pharmacy, Noakhali Science and Technology University, Noakhali-3814, Bangladesh

DOI:

https://doi.org/10.3329/jsr.v13i1.47324

Abstract

Bisoprolol is a type of antihypertensive drug (β-blocker). It is a poorly water-soluble and highly permeable drug that belongs to class II biopharmaceutical classification. This investigation represents the formulation development of bisoprolol to sustain the drug release. Different types of polymers like hypromellose, xanthan gum, avicel, poly ethylene glycol (PEG) were used in this study. Three different formulations were developed by using different excipients at various ratios. The granules were evaluated for bulk density, tapped density, flow property whereas tablets were evaluated for thickness, hardness, weight variation, compressibility index, uniformity of content, disintegration time, and drug release profile. The concentration of the diffused drug was measured using a UV-visible spectrophotometer at λmax= 225 nm. Granules showed good flow ability and all the formulations passed the quality. Among all the formulations, F-2 and F-3 showed better efficiency. PEG along with hypermellose, and guar gum showed a good combination for sustaining the drug release

Downloads

Download data is not yet available.
Abstract
728
pdf
486

Downloads

Published

2021-01-01

How to Cite

Masum, M., Ripon, M. A. R., Bhowmik, D. R., Amin, M. T., Arefin, S., & Hossain, M. S. (2021). Formulation, Development and Evaluation of Bisoprolol Sustained Release Tablets. Journal of Scientific Research, 13(1), 209–219. https://doi.org/10.3329/jsr.v13i1.47324

Issue

Section

Section B: Chemical and Biological Sciences