Antioxidant and Cytotoxic Properties of the Methanol Extract of <i>Argyreia argentea </i>Stem

Authors

  • T. Ahsan Department of Biochemistry and Molecular Biology, University of Chittagong
  • M. A. Rahman University of Chittagong
  • N. U. Ahmed Bangladesh Council for Scientific and Industrial Research (BCSIR), Chittagong
  • S. B. Uddin Department of Botany, University of Chittagong

DOI:

https://doi.org/10.3329/jsr.v2i3.4772

Keywords:

Argyreia argentea, DPPH, Ascorbic acid, Scavenging activity, Gallic acid.

Abstract

The antioxidant potential of Argyreia argentea methanol stem extract was evaluated by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging method. The extract showed very significant effect as antioxidant in comparison to ascorbic acid, a reference antioxidant. The radical scavenging activity showed by the extract was a dose dependent phenomenon. The extract at the concentration of 400 μg/ml among five different concentrations (10, 50, 100, 200, 400 μg/ml) showed the highest scavenging activity, 94.86%. The stem extract was also evaluated for its cytotoxic properties by measuring significant LC50 value in a Brine-Shrimp lethality bioassay. LC50 value of Argyreia argentea stem extract was found 939.18 μg/ml, at a 95% confidence limit, giving the lower and upper limits 608.98 and 2043.9 μg/ml, respectively.

 

Keywords: Argyreia argentea; DPPH; Ascorbic acid; Scavenging activity; Gallic acid.

 

© 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

 DOI: 10.3329/jsr.v2i3.4772               J. Sci. Res. 2 (3), 523-530 (2010)

 

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Author Biographies

T. Ahsan, Department of Biochemistry and Molecular Biology, University of Chittagong

Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, Bangladesh

M. A. Rahman, University of Chittagong

Assistant Professor

Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-4331, Bangladesh

N. U. Ahmed, Bangladesh Council for Scientific and Industrial Research (BCSIR), Chittagong

Bangladesh Council for Scientific and Industrial Research (BCSIR), Chittagong, Bangladesh

S. B. Uddin, Department of Botany, University of Chittagong

Associtate Professor

Department of Botany, University of Chittagong

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Published

2010-08-24

How to Cite

Ahsan, T., Rahman, M. A., Ahmed, N. U., & Uddin, S. B. (2010). Antioxidant and Cytotoxic Properties of the Methanol Extract of <i>Argyreia argentea </i>Stem. Journal of Scientific Research, 2(3), 621. https://doi.org/10.3329/jsr.v2i3.4772

Issue

Section

Section B: Chemical and Biological Sciences