Synthesis and Pharmacological Evaluation of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2-aryldenylamino)-benzo(1,3)thiazoles

Authors

  • G. Bannimath Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India
  • C. Sambireddy Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India
  • M. N. Purohit Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India
  • G. V. Pujar Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India

DOI:

https://doi.org/10.3329/jsr.v3i1.6166

Keywords:

Benzothiazole, Schiff’s base, Analgesic activity, Antiinflammatory activity.

Abstract

New series of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2-aryldenylamino)-benzo (1,3)thiazoles (Schiff’s base)(5a-g, 6a-g) were synthesized from 7-chloro-6-fluoro-2-(5-amino-oxazol/thiazol-2-amino)-benzothiazole (4a-b). Structures of the compounds were verified by 1H-NMR spectra. The synthesized compounds were screened for in vivo analgesic and antiinflammatory activities. Some of the compounds showed moderate activities.

Keywords: Benzothiazole; Schiff’s base; Analgesic activity; Antiinflammatory activity.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i1.6166                J. Sci. Res. 3 (1), 121-128 (2011)

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Author Biographies

G. Bannimath, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India

Dr. B.M.Gurupadayya,  M.Pharm., Ph.D.Professor
Dept. of Pharmaceutical ChemistryJ.S.S. College of Pharmacy, JSS UniversityS.S.Nagar,MYSORE-570 01, India. Tel: College: 91-821-2497583, 84, Fax: 91-821-2495900,  Cell:91-9242886136e mail:    bm_guru2004@yahoo.co.in 

C. Sambireddy, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India

Dept. of Pharmaceutical ChemistryJ.S.S. College of Pharmacy, JSS UniversityS.S.Nagar,MYSORE-570 01, India

M. N. Purohit, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India

Dept. of Pharmaceutical Chemistry J.S.S. College of Pharmacy, JSS UniversityS.S.Nagar,MYSORE-570 01, India.

G. V. Pujar, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysore-570 015, India

Dept. of Pharmaceutical Chemistry J.S.S. College of Pharmacy, JSS UniversityS.S.Nagar,MYSORE-570 01, India.

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Published

2010-12-20

How to Cite

Bannimath, G., Sambireddy, C., Purohit, M. N., & Pujar, G. V. (2010). Synthesis and Pharmacological Evaluation of 7-chloro-6-fluoro-2-(5-aminooxazol/thiazol-2-aryldenylamino)-benzo(1,3)thiazoles. Journal of Scientific Research, 3(1), 121. https://doi.org/10.3329/jsr.v3i1.6166

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Section

Section B: Chemical and Biological Sciences