Biotransformation of 11-ketoprogesterone by Filamentous Fungus, <i>Fusarium lini</i>

Authors

  • M. A. Al-Maruf Rajshahi University
  • N. T. Khan University of Karachi, Karachi-75270, Pakistan
  • M. A. A. Saki Rajshahi University
  • M. I. Choudhary University of Karachi, Karachi-75270, Pakistan
  • M. U. Ali Rajshahi University, Rajshahi-6205, Bangladesh
  • M. A. Islam Rajshahi University

DOI:

https://doi.org/10.3329/jsr.v3i2.6221

Keywords:

11-Ketoprogesterone, Steroid, Microbial transformation, Hydroxylation, Filamentous fungi, Fusarium lini.

Abstract

Microbial transformation of 11-ketoprogesterone (1) by the filamentous fungi Fusarium lini was investigated. Biotransformation of 1 with F. lini resulted in the production of ten oxidative metabolites (2-11). Structures of these metabolites were deduced by spectroscopic analysis and seven of them, 5-11, were found to be new metabolites.

Keywords: 11-Ketoprogesterone; Steroid; Microbial transformation; Hydroxylation; Filamentous fungi; Fusarium lini.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. 

doi:10.3329/jsr.v2i2.6221                J. Sci. Res. 3 (2), 347-356 (2011)

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Author Biographies

M. A. Al-Maruf, Rajshahi University

Ph.D Fellow

Department of Chemistry

Rajshahi University

N. T. Khan, University of Karachi, Karachi-75270, Pakistan

 Dr.  N. T. Khan

 H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan


* Corresponding author: maamaruf@gmail.com

M. A. A. Saki, Rajshahi University

M. A. A. Saki

 

Department of Chemistry, Rajshahi University, Rajshahi-6205, Bangladesh

 

 

M. I. Choudhary, University of Karachi, Karachi-75270, Pakistan

Prof. M. I. Choudhary

 

 

 

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan


 

M. U. Ali, Rajshahi University, Rajshahi-6205, Bangladesh

Prof M Umar Ali

Department of Chemistry

Rajshahi University

Rajshahi, Bangladesh

M. A. Islam, Rajshahi University

Prof. M. Azizul Islam

Department of Chemistry

Rajshahi University

Rajshahi, Bangladesh

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Published

2011-04-28

How to Cite

Al-Maruf, M. A., Khan, N. T., Saki, M. A. A., Choudhary, M. I., Ali, M. U., & Islam, M. A. (2011). Biotransformation of 11-ketoprogesterone by Filamentous Fungus, <i>Fusarium lini</i>. Journal of Scientific Research, 3(2), 347–356. https://doi.org/10.3329/jsr.v3i2.6221

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Section

Section B: Chemical and Biological Sciences