Synthesis and Spectral Studies of R(2),C(4)-Bis(Tert-Butoxycarbonyl)-C(5)-Hydroxy-T(5)-Methyl-T(3)-Phenyl Cyclohexanone and Their Biological Activity

Authors

  • T. Sumathi PG & Research Department of Chemistry, Govt. Arts College, C-Mutlur, Chidambaram. 608 102, Tamilnadu, India
  • B. Anandhan PG & Research Department of Chemistry, Govt. Arts College, C-Mutlur, Chidambaram. 608 102, Tamilnadu, India
  • P. Sivakumar Research Scholar, Saraswathi College of Eng, Tindivanam-604 305, Tamilnadu, India
  • S. Kamatchi PG & Research Department of Chemistry, Govt. Arts College, C-Mutlur, Chidambaram. 608 102, Tamilnadu, India

DOI:

https://doi.org/10.3329/jsr.v15i3.63806

Abstract

There are three new t(3)-aryl-r(2),c(4)-bis(tert-butoxycarbonyl)-c(5)-hydroxy-t(5)-methyl- cyclohexanones (1-3) have been synthesized by condensing tert-butyl acetoacetate with different aromatic aldehydes in the presence of methylamine as a stereospecific catalyst.  The structures of the products were confirmed by 1H NMR, 13C NMR, and IR spectroscopic techniques.  For compound (1), HMBC, HSQC, COSY, NOESY, and Mass spectra of the compounds were studied.  Elemental analysis was carried out for all the compounds. In vitro biological applications like anti-inflammatory and antioxidant activities were also performed. The tert-butoxycarbonyl cyclohexanones showed good anti-inflammatory and antioxidant activities, and the percentage of inhibitions is nearer to standard drugs.

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Author Biography

P. Sivakumar, Research Scholar, Saraswathi College of Eng, Tindivanam-604 305, Tamilnadu, India

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Published

2023-08-16

How to Cite

Sumathi, T., Anandhan, B., Sivakumar, P., & Kamatchi, S. (2023). Synthesis and Spectral Studies of R(2),C(4)-Bis(Tert-Butoxycarbonyl)-C(5)-Hydroxy-T(5)-Methyl-T(3)-Phenyl Cyclohexanone and Their Biological Activity. Journal of Scientific Research, 15(3), 807–817. https://doi.org/10.3329/jsr.v15i3.63806

Issue

Vol. 15 No. 3 (2023)

Section

Section B: Chemical and Biological Sciences

License

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© Journal of Scientific Research

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Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.