Cytotoxicity and Cancer (HeLa) Cell Killing Efficacy of Aqueous Garlic (<i>Allium sativum</i>) Extract

Authors

  • M. S. Islam kagoshima University
  • Y. Kusumoto Kagoshima University
  • M. Abdulla Al-Mamun Kagoshima University

DOI:

https://doi.org/10.3329/jsr.v3i2.6557

Keywords:

Aqueous garlic extract, Cancer cells, Cytotoxicity, Anticancer activity.

Abstract

Garlic (Allium sativum) is a herb that is used mainly as a food in many countries for its medicinal properties since ancient times. It enhances immune functions and has antibacterial, antifungal, antivirus and anticancer activities. Organosulfur compounds originating from garlic inhibit carcinogen activation. In this study we prepared aqueous garlic extract (AGE) and its in vitro application to cancer (HeLa) cell line was performed to observe the cancer cell killing efficacy. Different concentrations of AGE like 100, 200, 300, 400, and 500 µL per a 5-mL minimum essential medium solution were used for treatment. The results revealed that 95% cancer cells were destructed in a dose of 500 µL, whereas about 92, 87, 60, and 24% cancer cells were destructed in a dose of 400, 300, 200 or 100 µL of AGE, respectively.

Keywords: Aqueous garlic extract; Cancer cells; Cytotoxicity; Anticancer activity.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i2.6557                J. Sci. Res. 3 (2), 375-382 (2011)

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Author Biographies

M. S. Islam, kagoshima University

Department of System Information Science, Graduate School of Science and Engineering, PhD Student

Y. Kusumoto, Kagoshima University

Department of System Information Science, Graduate School of Science and Engineering

Professor

M. Abdulla Al-Mamun, Kagoshima University

Department of System Information Science, Graduate School of Science and Engineering

Post Doc. Researcher

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Published

2011-04-28

How to Cite

Islam, M. S., Kusumoto, Y., & Al-Mamun, M. A. (2011). Cytotoxicity and Cancer (HeLa) Cell Killing Efficacy of Aqueous Garlic (<i>Allium sativum</i>) Extract. Journal of Scientific Research, 3(2), 375–382. https://doi.org/10.3329/jsr.v3i2.6557

Issue

Section

Section B: Chemical and Biological Sciences