Ring Opening of Spiroepoxides Dithianedioxide with Bis-nucleophiles

Authors

  • R. Ritmaleni Gadjah Mada University, Jogjakarta, Indonesia
  • V. K. Aggarwal University of Bristol

DOI:

https://doi.org/10.3329/jsr.v3i3.6746

Keywords:

Amino alcohol, Morpholine ring, Spiroepoxide dithianedioxide, Amino acid.

Abstract

This research was aimed to apply the spiroepoxide dithianedioxide for the synthesis of amino acid via ring opening of the spiroepoxide by bis-nucleophiles. First attempt was made to synthesize the bis-nucleophiles, amino alcohol, which was eventually used to the ring opening reaction of the spiroepoxide to produce the morpholine ring compound. The reaction was carried out in racemic and asymmetric method with moderate yield and high 99%. The last step produced amino acid that was still remained unsuccessful. However, it cannot be concluded yet whether the spiroepoxide dithianedioxide is the right intermediate for the synthesis of amino acid.

Keywords:  Amino alcohol; Morpholine ring; Spiroepoxide dithianedioxide; Amino acid.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: 10.3329/jsr.v3i3.6746               J. Sci. Res. 3 (3), 585-596 (2011)

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Author Biography

V. K. Aggarwal, University of Bristol

School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK

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Published

2011-08-28

How to Cite

Ritmaleni, R., & Aggarwal, V. K. (2011). Ring Opening of Spiroepoxides Dithianedioxide with Bis-nucleophiles. Journal of Scientific Research, 3(3), 575–586. https://doi.org/10.3329/jsr.v3i3.6746

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Section

Section B: Chemical and Biological Sciences