Preliminary Investigation on Sodium Alginate Extracted from <i>Sargassum Subrepandum</i> of Red Sea of Eritrea as Tablet Binder

Authors

  • N. S. Basha Asmara College of Health Sciences,
  • R. Rekha SRM College of Pharmacy
  • A. Letensie Asmara College of Health Sciences
  • S. Mensura Asmara College of Health Sciences

DOI:

https://doi.org/10.3329/jsr.v3i3.6770

Keywords:

Sargassum subrepandum, Sodium alginate, Hydroxypropyl methylcellulose, Friability, Hardness, Disintegration.

Abstract

Natural polysaccharides hold advantages over synthetic polymers for conventional and novel dosage forms, because these are non-toxic, less expensive, and biodegradable. These can also be modified to tailor-made materials and thus can compete with the available synthetic excipients. Therefore, the aim of present work is to extract sodium alginate from the seaweed S. subrepandum to assess its binding property using propranolol as model drug. Sodium alginate was extracted by room-temperature alkaline extraction and high-temperature (80°C) alkaline extraction methods. Binding strength was evaluated by using two different formulations i.e., formulation 1 with sodium alginate as a binder and formulation 2 with hydroxypropylmethylcellulose (HPMC) as reference standard. The two tablet formulations were evaluated and compared for parameters such as friability, hardness and disintegration. The percentage yield was found to be 17.5% w/w by room-temperature alkaline extraction and 21%w/w by high-temperature extraction method. The results obtained for all tested parameters for tablets with sodium alginate were found within acceptable range of USP standards. It was also founded that both sodium alginate and HPMC have similar binding strength at similar concentration. So, it can be concluded that sodium alginate of S. subrepandum can be used as suitable alternative binder in tablet formulations.

Keywords: Sargassum subrepandum; Sodium alginate; Hydroxypropyl methylcellulose; Friability; Hardness; Disintegration.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i3.6770                     J. Sci. Res. 3 (3), 619-628 (2011)

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Author Biographies

N. S. Basha, Asmara College of Health Sciences,

Lecturer,
Department of Pharmaceutics,
School of Pharmacy,
Asmara College of Health Sciences,
P.O. Box. No: 8566
Asmara, Eritrea,
North East Africa.
Tel: 00291-7229332

R. Rekha, SRM College of Pharmacy

Department of Pharmacognosy, SRM College of Pharmacy, Kattangulathur, Chennai, Tamilnadu, India

A. Letensie, Asmara College of Health Sciences

Department of Pharmaceutics, School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea, NE Africa

 


S. Mensura, Asmara College of Health Sciences

Department of Pharmaceutics, School of Pharmacy, Asmara College of Health Sciences, Asmara, Eritrea, NE Africa

 

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Published

2011-08-29

How to Cite

Basha, N. S., Rekha, R., Letensie, A., & Mensura, S. (2011). Preliminary Investigation on Sodium Alginate Extracted from <i>Sargassum Subrepandum</i> of Red Sea of Eritrea as Tablet Binder. Journal of Scientific Research, 3(3), 609–618. https://doi.org/10.3329/jsr.v3i3.6770

Issue

Section

Section B: Chemical and Biological Sciences