Antitumor Activity of <i>Diospyros peregrina</i> on Ehrlich Ascites Carcinoma in Mice

Authors

  • A. B. Raju St.Peters Institute of Pharmaceutical sciences,Hanamkonda,Warangal,INDIA
  • Venu Gopal Y St. Peter?s Institute of Pharmaceutical sciences, Vidya Nagar, Warangal, A.P, India
  • Ravindranath A University College of Technology, Osmania University, Hyderabad A.P, India.
  • Kalpana G St.Peter?s Institute of Pharmaceutical sciences, Vidya Nagar, Warangal, A.P, India
  • Prabhakar Reddy V

DOI:

https://doi.org/10.3329/jsr.v3i2.6787

Keywords:

Diospyros Peregrina, Ehrlich ascites Carcinoma, Antitumor

Abstract

The methanol extract of Diospyros peregrina (Ebenaceae) bark (MEDP) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing swiss albino mice. The extract was administered at the doses of 200 and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MEDP on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile  MEDP caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MEDP exhibited significant antitumor activity in EAC-bearing mice.

Keywords: Diospyros peregrina; Ehrlich ascites carcinoma; Antitumor.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i2.6787                J. Sci. Res. 3 (2), 413-419 (2011)

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Author Biography

A. B. Raju, St.Peters Institute of Pharmaceutical sciences,Hanamkonda,Warangal,INDIA

202,B Block,VUDA Aprtamnets,Sethammdhara ,vIsakhapatnam,A.P,India.

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Published

2011-04-28

How to Cite

Raju, A. B., Y, V. G., A, R., G, K., & V, P. R. (2011). Antitumor Activity of <i>Diospyros peregrina</i> on Ehrlich Ascites Carcinoma in Mice. Journal of Scientific Research, 3(2), 413–419. https://doi.org/10.3329/jsr.v3i2.6787

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Section

Section B: Chemical and Biological Sciences