Encapsulation of Biologically Potent Neurotransmitters into HP-β-CD Probed by Physicochemical Approach simultaneously Optimized by Computational Studies

Authors

  • F. Alam Department of Chemistry, University of North Bengal, Darjeeling-734013, India
  • S. B. Neogi Department of Chemistry, University of North Bengal, Darjeeling-734013, India; Department of Chemistry, Darjeeling Govt. College, Darjeeling-734101, India
  • A. Das Department of Chemistry, University of North Bengal, Darjeeling-734013, India
  • N. Roy Department of Chemistry, University of North Bengal, Darjeeling-734013, India
  • A. Hossain Department of Chemistry, University of North Bengal, Darjeeling-734013, India
  • M. Kundu Department of Chemistry, University of North Bengal, Darjeeling-734013, India
  • L. Sarkar Department of Chemistry, Siliguri College, Darjeeling-734001, India
  • M. N. Roy Department of Chemistry, University of North Bengal, Darjeeling-734013, India

DOI:

https://doi.org/10.3329/jsr.v16i3.69752

Abstract

The inclusion complexes of the neurotransmitters, namely (±) epinephrine hydrochloride, dopamine hydrochloride, and tyramine hydrochloride in an aqueous medium, were studied physicochemically and spectroscopically. These rendered systems of drug delivery with the potential to ensure delivery to desired targets. The stoichiometry of the 1:1 ratio of host-guest binding was established using Job plots. Conductimetric studies gained an understanding of inclusion as a process. Furthermore, 1H NMR was used to characterize the inclusions, and the Benesi Hildebrand equation was applied to obtain the association constants. Thermodynamics, which are important in predicting the feasibility of any process, were in favor of inclusion as obtained by the evaluation of various thermodynamic parameters from Van᾿t Hoff's equation.

 

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Published

2024-09-02

How to Cite

Alam, F., B. Neogi, S., Das, A., Roy, N., Hossain, A., Kundu, M., Sarkar , L., & Roy, M. N. (2024). Encapsulation of Biologically Potent Neurotransmitters into HP-β-CD Probed by Physicochemical Approach simultaneously Optimized by Computational Studies. Journal of Scientific Research, 16(3), 783–801. https://doi.org/10.3329/jsr.v16i3.69752

Issue

Vol. 16 No. 3 (2024)

Section

Section B: Chemical and Biological Sciences

License

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© Journal of Scientific Research

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Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.