Synthesis, Antitumor and Antimicrobial Activities of Some Novel 1-(Substituted)-3-Methyl-1<i>H</i>-Pyrazol-5(4<i>H</i>)-One

Authors

  • R. V. Antre
  • A. Cendilkumar
  • R. R. Nagarajan
  • D. Goli
  • R. J. Oswal

DOI:

https://doi.org/10.3329/jsr.v4i1.7027

Keywords:

Ehrlich Ascites Carcinoma (EAC), Pyrazolone, Antitumor, N-substitution, Antimicrobial.

Abstract

Several 1-(substituted)-3-methyl-1H-pyrazol-5(4H)-one as RA1-RA9 were synthesized and compounds were screened for antitumor activity against Ehrlich ascites carcinoma (EAC) cells and antimicrobial activity. Elemental analysis, mass spectral data, 1H-NMR, and IR confirmed the structure of the newly synthesized compounds. Some of the tested compounds showed good antitumor and antimicrobial activity. Compounds RA1, RA4, and RA9 exhibit highest antitumor activity against EAC cells in comparison with 5-flurouracil as standard drug.

Keywords: Ehrlich ascites carcinoma; Pyrazolone; Antitumor; N-substitution; Antimicrobial.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i1.7027

 

J. Sci. Res. 4 (1), 183-192 (2012)

Downloads

Download data is not yet available.
Abstract
192
PDF
444

Author Biographies

R. V. Antre

Mr. Antre Rishikesh Vilas* (M. Pharmacy, PhD.)

Medicinal Chemistry Research Laboratory, Acharya & B.M. Reddy College of Pharmacy, 89/90, Soldevanahalli, Chikkabanavara post, Heseraghatta main road, Bangalore- 560 090 State: Karnataka

A. Cendilkumar

A. Cendilkumar

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India

R. R. Nagarajan

R. Nagarajan

Organic Chemistry Research Laboratory, School of Chemistry, University of Hyderabad, Central University (P.O.), Hyderabad, Andhrapradesh 500046, India

D. Goli

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India


R. J. Oswal

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India

Downloads

Published

2011-12-26

How to Cite

Antre, R. V., Cendilkumar, A., R. Nagarajan, R., Goli, D., & Oswal, R. J. (2011). Synthesis, Antitumor and Antimicrobial Activities of Some Novel 1-(Substituted)-3-Methyl-1<i>H</i>-Pyrazol-5(4<i>H</i>)-One. Journal of Scientific Research, 4(1), 183. https://doi.org/10.3329/jsr.v4i1.7027

Issue

Vol. 4 No. 1 (2012)

Section

Section B: Chemical and Biological Sciences

License

© Journal of Scientific Research

Creative Commons License

Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.