Synthesis, Antitumor and Antimicrobial Activities of Some Novel 1-(Substituted)-3-Methyl-1<i>H</i>-Pyrazol-5(4<i>H</i>)-One

Authors

  • R. V. Antre
  • A. Cendilkumar
  • R. R. Nagarajan
  • D. Goli
  • R. J. Oswal

DOI:

https://doi.org/10.3329/jsr.v4i1.7027

Keywords:

Ehrlich Ascites Carcinoma (EAC), Pyrazolone, Antitumor, N-substitution, Antimicrobial.

Abstract

Several 1-(substituted)-3-methyl-1H-pyrazol-5(4H)-one as RA1-RA9 were synthesized and compounds were screened for antitumor activity against Ehrlich ascites carcinoma (EAC) cells and antimicrobial activity. Elemental analysis, mass spectral data, 1H-NMR, and IR confirmed the structure of the newly synthesized compounds. Some of the tested compounds showed good antitumor and antimicrobial activity. Compounds RA1, RA4, and RA9 exhibit highest antitumor activity against EAC cells in comparison with 5-flurouracil as standard drug.

Keywords: Ehrlich ascites carcinoma; Pyrazolone; Antitumor; N-substitution; Antimicrobial.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i1.7027

 

J. Sci. Res. 4 (1), 183-192 (2012)

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Author Biographies

R. V. Antre

Mr. Antre Rishikesh Vilas* (M. Pharmacy, PhD.)

Medicinal Chemistry Research Laboratory, Acharya & B.M. Reddy College of Pharmacy, 89/90, Soldevanahalli, Chikkabanavara post, Heseraghatta main road, Bangalore- 560 090 State: Karnataka

A. Cendilkumar

A. Cendilkumar

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India

R. R. Nagarajan

R. Nagarajan

Organic Chemistry Research Laboratory, School of Chemistry, University of Hyderabad, Central University (P.O.), Hyderabad, Andhrapradesh 500046, India

D. Goli

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India


R. J. Oswal

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy; Bangalore, Karnataka 560090, India

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Published

2011-12-26

How to Cite

Antre, R. V., Cendilkumar, A., R. Nagarajan, R., Goli, D., & Oswal, R. J. (2011). Synthesis, Antitumor and Antimicrobial Activities of Some Novel 1-(Substituted)-3-Methyl-1<i>H</i>-Pyrazol-5(4<i>H</i>)-One. Journal of Scientific Research, 4(1), 183. https://doi.org/10.3329/jsr.v4i1.7027

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Section

Section B: Chemical and Biological Sciences