6-Bromo-1H-Indazole Bearing 1,2,3-Triazole Analogues: Synthesis, Characterization and Antimicrobial Evaluation

Authors

  • N. P. Savaniya Department of Chemistry, Government Science College, Ahwa, Dist. Dangs-394710, Gujarat, India
  • A. D. Khakhariya Department of Chemistry, Shri M. & N. Virani Science College, Rajkot-360005, Gujarat, India
  • P. P. Pankhaniya Department of Chemistry, Shri M. & N. Virani Science College, Rajkot-360005, Gujarat, India
  • K. D. Ladva Department of Chemistry, Shri M. & N. Virani Science College, Rajkot-360005, Gujarat, India

DOI:

https://doi.org/10.3329/jsr.v17i1.72947

Abstract

This research paper covers the synthesis of novel pharmaceutically active and high yield scaffolds with easier pathway. A series of novel 1,2,3-traizole derivatives tethered with 6-bromo-1H-indazole were synthesized using various 2-azido-N-arylacetamide derivatives via 1,3-dipolar cycloaddition reaction. Structural evaluation was carried out using different analytical techniques such as IR, Mass and 1H-NMR spectroscopy. Further, newly synthesized molecules were evaluated for their antimicrobial efficacy using different bacterial and fungal strains. Several of these synthesized derivatives expressed moderate to good inhibition in comparison with standard drugs.

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Published

2025-01-01

How to Cite

Savaniya, N. P., Khakhariya, A. D., Pankhaniya, P. P., & Ladva, K. D. (2025). 6-Bromo-1H-Indazole Bearing 1,2,3-Triazole Analogues: Synthesis, Characterization and Antimicrobial Evaluation. Journal of Scientific Research, 17(1), 287–296. https://doi.org/10.3329/jsr.v17i1.72947

Issue

Section

Section B: Chemical and Biological Sciences