<i>In vitro</i> Transdermal Delivery of Metformin from a HPMC/ PVA Based TDS-patch at Different pH

Authors

  • L. Jahan Manarat International University
  • R. Ferdaus Rajshahi University
  • S. M. Shaheen University of Rajshahi
  • M. Z. Sultan University of Dhaka
  • M. A. Mazid University of Dhaka

DOI:

https://doi.org/10.3329/jsr.v3i3.7422

Keywords:

Transdermal drug delivery, Higuchi diffusion, Release rate, Metformin.

Abstract

In order to evaluate the pHs effect on the transdermal drug delivery, HPMC/PVA based TDS-patch was prepared. In vitro transdermal dissolution was performed at 32 oC at different pHs.  Comparatively higher release rate was found in case of pH 7.4 than those of others. pHs 5.4 and 8 showed almost the same release pattern. The release fashion was Higuchi type of diffusion controlled release. This result showed that neutral pH would accumulate the maximum drug from such a TDS patch, where the skin pH (around 5.4)  does not support such a release. Sustained release of drug from such a patch prefers skin pH rather than neutral pH.

Keywords: Transdermal drug delivery; Higuchi diffusion; Release rate; Metformin.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi:10.3329/jsr.v3i3.7422               J. Sci. Res. 3 (3), 661-667 (2011)

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Author Biographies

L. Jahan, Manarat International University

Lecturer, Department of Pharmacy, Manarat International University, Gulshan, Dhaka, Bangladesh

 

R. Ferdaus, Rajshahi University

Department of Pharmacy

Rajshahi Universityy

Bangladesh

S. M. Shaheen, University of Rajshahi

Associate Professor, Department of Pharmacy

M. Z. Sultan, University of Dhaka

Post Doctoral Fellow, Drug Research Lab, Centre for Advanced Research in Sciences

M. A. Mazid, University of Dhaka

Associate Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy

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Published

2011-08-29

How to Cite

Jahan, L., Ferdaus, R., Shaheen, S. M., Sultan, M. Z., & Mazid, M. A. (2011). <i>In vitro</i> Transdermal Delivery of Metformin from a HPMC/ PVA Based TDS-patch at Different pH. Journal of Scientific Research, 3(3), 651–657. https://doi.org/10.3329/jsr.v3i3.7422

Issue

Section

Section B: Chemical and Biological Sciences