Preliminary Cytotoxicity and Antimicrobial Investigation of <i>Anthocaphalus chinensis</i>

Authors

  • M. A. Hossain University of Dhaka, Dhaka-1000
  • M. Z. Sultan Centre for Advanced Research in Sciences, University of Dhaka
  • A. M. S. Chowdhury University of Dhaka, Dhaka-1000
  • C. M. Hasan University of Dhaka, Dhaka-1000
  • M. A. Rashid University of Dhaka, Dhaka-1000

DOI:

https://doi.org/10.3329/jsr.v3i3.7529

Keywords:

Anthocephalus chinensis, Rubiaceae, Cytotoxicity, Antimicrobial.

Abstract

The methanol extract of the stem bark of Anthocephalus chinensis as well as its n-hexane, carbon tetrachloride, chloroform and aqueous soluble fractions were subjected to brine shrimp lethality bioassay and microbiological investigation. In the brine shrimp lethality bioassay, the aqueous soluble partitionate of the methanolic extract revealed the highest cytotoxicity having LC50 of 1.19 mg/ml while in case of antimicrobial screening, the chloroform soluble materials demonstrated moderate inhibition of growth of test organisms.

Keywords: Anthocephalus chinensis; Rubiaceae; Cytotoxicity; Antimicrobial.

© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: 10.3329/jsr.v3i3.7529               J. Sci. Res. 3 (3), 689-692 (2011)

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Author Biographies

M. A. Hossain, University of Dhaka, Dhaka-1000

Ph.D. researcher, Department of Applied Chemistry and Chemical Engineering

M. Z. Sultan, Centre for Advanced Research in Sciences, University of Dhaka

Post Doc. Fellow, Drug Research Lab.

A. M. S. Chowdhury, University of Dhaka, Dhaka-1000

Professor, Department of Applied Chemistry and Chemical Engineering

C. M. Hasan, University of Dhaka, Dhaka-1000

Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,and Centre for Biomedical Research, University of Dhaka, Dhaka-1000, Bangladesh

 

M. A. Rashid, University of Dhaka, Dhaka-1000

Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,and Centre for Biomedical Research, University of Dhaka, Dhaka-1000, Bangladesh

 

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Published

2011-08-30

How to Cite

Hossain, M. A., Sultan, M. Z., Chowdhury, A. M. S., Hasan, C. M., & Rashid, M. A. (2011). Preliminary Cytotoxicity and Antimicrobial Investigation of <i>Anthocaphalus chinensis</i>. Journal of Scientific Research, 3(3), 689–692. https://doi.org/10.3329/jsr.v3i3.7529

Issue

Section

Section B: Chemical and Biological Sciences