Synthesis, Antibacterial and Antifungal Activity of N’-(3-Hydroxy-4-Methoxy Benzylidene) Adamantane-1-Carbohydrazide (IVAC) and Its Isomers

Authors

  • D. D. Parab Department of Chemistry, G. N. Khalsa College of Arts, Science & Commerce, (Autonomous), Matunga, Mumbai-400019, Mumbai University, Maharashtra, India
  • H. K. Kohli Department of Chemistry, G. N. Khalsa College of Arts, Science & Commerce, (Autonomous), Matunga, Mumbai-400019, Mumbai University, Maharashtra, India

DOI:

https://doi.org/10.3329/jsr.v17i2.75876

Abstract

Novel 1-adamantyl derivatives were designed, synthesized and evaluated for anti-bacterial activity against Gram-negative bacteria, Escherichia coli, Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis and for antifungal activity against pathogen Candida albicans. The screening results indicated that the synthesised compounds N’-(3-hydroxy-4-methoxy benzylidene) adamantane-1-carbohydrazide (IVAC) and its isomers exhibited substantial antibacterial and antifungal properties when compared with known drug Ampicillin. The Minimum inhibitory concentration, MIC value obtained was less than 1.95 μg/ml. The structural features of IVAC and its isomers were confirmed by 1H-NMR, FTIR, and elemental analysis.

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Published

2025-05-01

How to Cite

Parab, D. D., & Kohli, H. K. (2025). Synthesis, Antibacterial and Antifungal Activity of N’-(3-Hydroxy-4-Methoxy Benzylidene) Adamantane-1-Carbohydrazide (IVAC) and Its Isomers. Journal of Scientific Research, 17(2), 547–560. https://doi.org/10.3329/jsr.v17i2.75876

Issue

Vol. 17 No. 2 (2025)

Section

Section B: Chemical and Biological Sciences

License

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© Journal of Scientific Research

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