Analgesic and anti-inflammatory effect of Clausena suffruticosa root extract in animal model

Authors

  • M. A. Rahman University of Chittagong
  • J. S. Chakma University of Chittagong
  • S. Islam BCSIR, Chittagong
  • M. S. Rana University of Chittagong
  • N. U. Ahmed BCSIR, Ctg

DOI:

https://doi.org/10.3329/jsr.v3i3.7594

Keywords:

Analgesic, Anti-inflammatory, Clausena suffruticosa, Ethanolic extract

Abstract

The aim of the study was to evaluate the analgesic and anti-inflammatory effects of Clausena suffruticosa root extract. The effect of different concentrations of ethanolic root extract were studied in animal model using acetic acid induced writhing response, formalin induced pain, hot plate method for analgesic activity in Swiss Albino mice and carrageenan induced paw edema for anti-inflammatory action in Wister Albino rat. The extract reduced writhing response 20% by 0.5g/kg, 57.6% by 1.5g/kg and 78% by 2 g/kg and showed significant analgesic activity as determined by formalin induced pain and hot plate method. In the carrageenan induced paw edema, the extract at a dose of 0.5, 1.0 and 2.0 g/kg showed the highest inhibition 17.23%, 26.30% and 42.46%, respectively, at the 4th hour of administration. The results indicate that the extract shows promising analgesic effect in chemical models of nociception (not related to the opioid system) and anti-inflammatory effect.

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Author Biographies

M. A. Rahman, University of Chittagong

Assistant Professor

J. S. Chakma, University of Chittagong

Student

S. Islam, BCSIR, Chittagong

Scientific Officer

M. S. Rana, University of Chittagong

Student

N. U. Ahmed, BCSIR, Ctg

Scientific Officer

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Published

2011-08-30

How to Cite

Rahman, M. A., Chakma, J. S., Islam, S., Rana, M. S., & Ahmed, N. U. (2011). Analgesic and anti-inflammatory effect of Clausena suffruticosa root extract in animal model. Journal of Scientific Research, 3(3), 631–639. https://doi.org/10.3329/jsr.v3i3.7594

Issue

Section

Section B: Chemical and Biological Sciences