<i>In vitro</i> Interaction of Metronidazole and Mebendazole with Copper (II) and Chromium (III) in Aqueous Media

Authors

  • A. T. M. Z. Azam University of Dhaka
  • F. Siraji Dhaka University Dhaka-1000
  • M. S. Amran Dhaka University
  • J. N. Islam University of Chittagong
  • F. M. Amjad Dhaka Medical College Hospital
  • M. A. Hossain Dhaka University

DOI:

https://doi.org/10.3329/jsr.v4i1.7599

Keywords:

Metronidazole, Mebendazole, Cu(II), Cr(III), Ardon’s plot, Complexation.

Abstract

The interaction of metronidazole, an antiprotozoal agent and mebendazole, an important anthelmentic agent with Cu (II) and Cr(III) ions have been studied in aqueous systems at a fixed temperature of 37±0.5°C  and at different pH values. It has been found that metronidazole and mebendazole form stable 1:1 complexes with Cu(II), but a less stable complex with Cr(III) ion.  The studies were performed by electroanalytical and spectrophotometric methods. Spectral studies helped to detect initial complexation between the species. Conductometric titration indicated the nature of interaction and the stoichiometries of complexation. The conductometric study also indicated the formation of complexes of various molar ratios viz 1:2, 4:1, 3:1, 1:2, 1:3 and 1:4. etc. along with 1:1 complexes at various pH conditions. Similar types of complexation were observed by Job’s plots at various pH values. The Ardon’s spectroscopic method confirmed the 1:1 complexation and the values of stability constant were calculated using Ardon’s plot. Complexation at molar ratios 1:3 and 1:4 can not be ruled out.

Keywords:  Metronidazole; Mebendazole; Cu(II); Cr(III); Ardon’s plot; Complexation.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i1.7599

J. Sci. Res. 4 (1), 173-181 (2012)

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Author Biographies

A. T. M. Z. Azam, University of Dhaka

Associate Professor

Department of Pharmaceutical Chemistry
Faculty of Pharmacy
Dhaka University

F. Siraji, Dhaka University Dhaka-1000

Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Dhaka University
Dhaka-1000

M. S. Amran, Dhaka University

Associate Professor

Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Dhaka University
Dhaka-1000

J. N. Islam, University of Chittagong

Professor

Research Center for Mathematical and Physical Sciences, University of Chittagong, Chittagong

F. M. Amjad, Dhaka Medical College Hospital

Medical Officer

Dhaka Medical College Hospital, Dhaka-1000, Bangladesh

M. A. Hossain, Dhaka University

Professor

Department of Pharmaceutical Chemistry
Faculty of Pharmacy, Dhaka University
Dhaka-1000

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Published

2011-12-26

How to Cite

Azam, A. T. M. Z., Siraji, F., Amran, M. S., Islam, J. N., Amjad, F. M., & Hossain, M. A. (2011). <i>In vitro</i> Interaction of Metronidazole and Mebendazole with Copper (II) and Chromium (III) in Aqueous Media. Journal of Scientific Research, 4(1), 173. https://doi.org/10.3329/jsr.v4i1.7599

Issue

Section

Section B: Chemical and Biological Sciences