Synthesis of Biheterocycles Containing Indole Nucleus and Their Antibacterial Activity
Keywords:Indole-3-carboxaldehydes, Active methylene compounds, Base, Hydrazine hydrat, , Pyrazoles
Indole-3-carboxaldehydes (1a-d) undergo condensation with ethyl cyanoacetate and malononitrile to give the acrylonitrile 2a-d and 3a-d which on reaction with hydrazine hydrate yield 3,5-diamino-5-hydroxy-4-(3-indolylmethylene)pyrazoles (4a-d) and 3-amino-5-hydroxy -4-(3-indolylmethylene)pyrazoles (5a-d), respectively. The new compounds were also screened for their antibacterial activity.
Keywords: Indole-3-carboxaldehydes ; Active methylene compounds; Base; Hydrazine hydrate; Pyrazoles.
© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.
J. Sci. Res. 4 (1), 273-278 (2012)
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