Negative Inotropic and Chronotropic Effects of Phenolic Fraction from <i>Cynodon dactylon</i> (linn) on Isolated Perfused Frog Heart

Authors

  • M. Mohamed Shabi Department of Pharmacology, Amrita School of Pharmacy, Amrita Institute of Medical Science (AIMS), Amrita Vishwa Vidyapeetham University, Kochi-682041, Kerala
  • C. David Raj Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur-613 402, Tamil Nadu
  • C. Sasikala Masterskill University College of Health Sciences, G-8, Jalan Kemacahya, Batu 943200 Cheras, Selangor
  • K. Gayathri Centre for Advanced Research in Indian System of Medicine (CARISM), SASTRA University, Thanjavur-613 402, Tamil Nadu
  • J. Joseph Department of Pharmacology, Amrita School of Pharmacy, Amrita Institute of Medical Science (AIMS), Amrita Vishwa Vidyapeetham University, Kochi-682041, Kerala

DOI:

https://doi.org/10.3329/jsr.v4i3.8549

Keywords:

Cynodon dactylon, Hydroquinone, GC-MS, Inotropic, Chronotropic

Abstract

Cynodon dactylon (L.) Pers belongs to the family Poaceae is a grass native to North Africa, Asia and Australia and southern Europe. The phenolic fraction of Cynodon dactylon (Linn) (CDP) was evaluated for its cardio-protective activity using isolated frog´s heart perfusion method. The negative inotropic and chronotropic activities were recorded using kymograph. The CDP produced negative inotropic and chronotropic actions on isolated frog heart. The pharmacological effect was selectively inhibited by atropine indicating that these might have been mediated through muscarinic receptor.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i3.8549 J. Sci. Res. 4 (3), 657-663 (2012)

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Published

2012-08-28

How to Cite

Mohamed Shabi, M., David Raj, C., Sasikala, C., Gayathri, K., & Joseph, J. (2012). Negative Inotropic and Chronotropic Effects of Phenolic Fraction from <i>Cynodon dactylon</i> (linn) on Isolated Perfused Frog Heart. Journal of Scientific Research, 4(3), 657–663. https://doi.org/10.3329/jsr.v4i3.8549

Issue

Section

Section B: Chemical and Biological Sciences