Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities

Authors

  • M. H. Bhuiyan Chemistry, Chittagong University
  • H. Nessa Chittagong University
  • M. M. Mahmud Chitagong University

DOI:

https://doi.org/10.3329/jsr.v4i1.8688

Keywords:

Multicomponent reactions, Dihydropyrimidinone, Microwave irradiation, Antimicrobial activity.

Abstract

Microwave promoted diammonium hydrogen phosphate, (NH4)2HPO4, catalyzed three-component Biginelli reaction between an aldehyde, a 1,3-dicarbonyl compound and urea or thiourea under solvent-free conditions afforded the corresponding dihydropyrimidinones and quinazolinones in high yields. The synthesized compounds have been screened for their antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio choloriae, Shigella dysenteriae, Salmonella typhi bacteria and Aspargilllus flavus, Saccharomyces cerevisiae and Candida albicans fungi respectively. Some of the synthesized compounds exhibited pronounced antimicrobial activities.

Keywords: Multicomponent reactions; Dihydropyrimidinone; Microwave irradiation; Antimicrobial activity.

© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.

doi: http://dx.doi.org/10.3329/jsr.v4i1.8688

J. Sci. Res. 4 (1), 143-153 (2012)

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Author Biographies

M. H. Bhuiyan, Chemistry, Chittagong University

Professor

Dept Chemistry

Chittagong University

Chittagng

H. Nessa, Chittagong University

Hamidunnessa

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Published

2011-12-26

How to Cite

Bhuiyan, M. H., Nessa, H., & Mahmud, M. M. (2011). Multicomponent Reactions: Microwave-assisted Efficient Synthesis of Dihydropyrimidinones (thiones) and Quinazolinones under Green Chemistry Protocol as Probes for Antimicrobial Activities. Journal of Scientific Research, 4(1), 143. https://doi.org/10.3329/jsr.v4i1.8688

Issue

Section

Section B: Chemical and Biological Sciences