The study of in Vitro Interaction of Ciprofloxacin with Paracetamol and Zinc in Aqueous Medium
DOI:
https://doi.org/10.3329/jsr.v4i3.8709Keywords:
Ciprofloxacin, Paracetamol, Zinc sulfate, Drug-drug interaction, Drug-metal interaction, Complexation.Abstract
Concurrent administration of more than one drug is a common practice in medical science and in such case one drug may affect the pharmacology of another drug. Ciprofloxacin is a commonly used antibiotic in Bangladesh and frequently prescribed with paracetamol and zinc salt for concomitant use in patients suffering from infections. Therefore, the interaction of ciprofloxacin with paracetamol and zinc salt was studied in vitro at pH 1.2, 6.8 and 7.4 which are related to gastric, intestinal juices and blood, respectively. Analysis of drug-drug and drug-metal complexation was carried out by using UV/VIS spectrophotometer as well as the conductometric titration. It was observed that ciprofloxacin formed complex with paracetamol and zinc at pH 1.2.
© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.
doi: http://dx.doi.org/10.3329/jsr.v4i3.8709 J. Sci. Res. 4 (3), 701-708 (2012)
Downloads
251
321
Downloads
Published
How to Cite
Issue
Section
License
© Journal of Scientific Research
Articles published in the "Journal of Scientific Research" are Open Access articles under a Creative Commons Attribution-ShareAlike 4.0 International license (CC BY-SA 4.0). This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and initial publication in this journal. In addition to that, users must provide a link to the license, indicate if changes are made and distribute using the same license as original if the original content has been remixed, transformed or built upon.