Efficacy of Topical Mometasone Furoate 0.1% Cream in the Treatment of Atopic Dermatitis

Abstract

A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka to evaluate the efficacy of Mometasone Furoate 0.1% cream in atopic dermatitis. Forty patients of atopic dermatitis were selected and randomized into two groups. In Group I, study patients were applied Mometasone Furoate 0.1% cream to the affected skin and in Group II, control patients were allowed to apply white vaseline to the affected skin. SCORAD index was assessed fortnightly at 2^nd and 3^rdvisit and final SCORAD index were calculated at the end of 4 week (3^rd visit). In the study, at base line SCORAD index in case group was 49.76 ± 17.25 and in control group was 55.25 ± 13.94 (p>0.05). At 2^nd visit that is at the end of 2 (two) weeks of medication SCORAD in case group was 27.39 ± 11.16 and in control group was 50.05 ± 14.69 (p=0.001) and at 3^rd visit that is at the end of 4 (four) weeks of medication in case group SCORAD was 12.08 ± 6.87 and in control group was 46.70 ± 14.80 (p=0.001). Percent of reduction of SCORAD from 1^st visit to 3^rd visit in case group was 76.70 ± 8.10 and in control group was 16.88 ± 8.70 (p=0.001) which indicates satisfactory improvement and statistically significant. It can be concluded that once daily application of mometasone furoate 0.1% cream is effective in atopic dermatitis.

DOI: http://dx.doi.org/10.3329/medtoday.v26i1.21311

Medicine Today 2014 Vol.26(1): 36-40