In the Pre-eclamp sia and Normotensive Patient- Lipid Profile Study

Abstract

Pre-eclampsia is associated with substantial risks for the fetus and mother. Disorders of lipoprotein metabolism are reported to be a major cause of hypertension and proteinuria in pre-eclampsia. This was a cross-sectional comparative study carried out in the Department of Obstetrics and Gynecology, Sylhet, M.A.G Osmani Medical College Hospital, Sylhet during December 2013 to May 2014. 50 pre-eclampsia and 50 normotensive pregnant women's serum lipid profile were selected according to inclusion and exclusion criteria. Fasting lipid profile was measured after 10-12 hours overnight fasting. The mean age (25.12 # 3.98 years vs 24.94 # 3.90 years; p=0.820), gestational age (36.80 # 0.70 weeks vs 36.9 # 1.1 weeks ; p=0.144), and BMI (21.43 # 2.09kg/M² vs 22.02 # 1.73kg/M², p=0.131) were statistically similar in both pre-eclamptic women and the control pregnant women. SBP (163.70 #11.24mm of Hg vs 115.10 # 9.39mm of Hg; p<0.001) and DBP (103.6 #9.4mm of Hg vs 71.50 #5.37mm of Hg p<0.001) were significantly higher in pre-eclamptic women than that of normotensive pregnant women. Serum total cholesterol (227.56 # 55.79mg/dl vs 194.56 # 43.33mg/dl, p=0.001). serum LDL-cholesterol (147.72 #51.03mg/dl vs 119.43 # 37.17mg/dl; p=0.002) and serum triglyceride (232.06 # 65.54mg/dl vs 157.44 # 64.24mg/dl p<0.001) were significantly higher in pre- eclampsia than that of normal pregnancy; while serum HDL- cholesterol (38.96 # 2.93 mg/dl vs 45.82 # 6.11 mg/dl; p <0.001) was significantly lower in pre-eclampsia than that of control pregnancy. An abnormal lipid profile has a direct effect on endothelial dysfunction. Early detection of these parameters may help patient by preventing complications in pre-eclampsia.

Medicine Today 2017 Vol.29(2): 1-4