Recent Trend of Bacteriological Profile and Drug Sensitivity Pattern of Neonatal Septicemia in A Tertiary Care Hospital in Bangladesh

Authors

  • Maksudur Rahman Associate Professor, Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka
  • BH Nazma Yasmeen Professor and Head, Dept. of Paediatrics, Northern International Medical College (NIMC), Dhaka
  • Nishat Jahan Registrar, Dept. of Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka
  • Md Mahbubul Hoque Professor, Dept. of Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka
  • Swapan Kumar Halder Assistant professor, Paediatrics Sher-e-Bangla Medical College (SBMC), Barisal
  • Ashis Halder Assistant professor, Paediatrics SBMC, Barisal
  • Nondini Rahman Nupur Resident, MD, Dept. of Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka
  • Israt Jahan Zerin Resident, MD, Dept. of Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka
  • Fatema Akter Rini Resident, MD, Dept. of Neonatology Bangladesh Institute of Child Health (BICH), Dhaka Shishu (Children) Hospital, Dhaka

DOI:

https://doi.org/10.3329/nimcj.v11i1.50738

Keywords:

Septicaemia, Neonatal sepsis.

Abstract

Background : In Bangladesh about 67% of under-five mortality is neonatal mortality. One of three major causes of neonatal morbidity and mortality is septicemia. Recently there is increasing incidence of multidrug resistant neonatal organisms which is alarming.

Objective : The aim of this study was to see the bacteriological profile and drug sensitivity pattern of neonatal septicemia.

Methods : This prospective observational study was done in Dhaka Shishu (children) Hospital over one-year period from June 2018 to May 2019. The admitted neonates were suspected as neonatal septicemia considering the risk factors, clinical profile and investigations (CBC, CRP etc.). Blood from all suspected neonatal septicemia cases were sent for culture and drugs sensitivity along with others necessary investigations. Then data was analyzed with SPSS version-20.

Results : Among the suspected cases only 111(10%) patients were culture positive. Preterm were 77(69%) and term 34(31%). One hundred six cases (95%) had sepsis with gram negative organisms and 5(5%) had sepsis with gram positive organisms with more predominant of Klebsiella (76,68%) followed by Acinetobacter (16,14%), Pseudomonas (6,5%), Escherichia coli (3,3%). Majority 80 (72%) cases had Early onset neonatal sepsis (EONS). Klebsiella (57, 51%) was more common organism followed by Acinetobacter (11,10 %) causing EONS and in late onset neonatal sepsis (LONS), similar type of causative organism were found. Ampicillin, Gentamicin and Ceftazidime were mostly resistance to gram negative organisms - 104(94%), 99(89%) and 93(84%) respectively. Besides these, Amikacin (104,94%), Imipenem (85, 77%) and Ciprofloxacin (73, 66%) were more resistance. Klebsiella in 17 cases and Acinetobacter in 4 cases were resistant to all commonly used antibiotics.

Conclusion : Klebsiella followed by Acinetobacter and Pseudomonas are now common pathogens of neonatal septicemia found in this study. Ampicillin, Gentamicin and Ceftazidime are more resistant to most of the organisms causing neonatal sepsis. Imipenem is alarmingly resistant. In 19% cases, the organisms are resistance to all commonly used antibiotics.

Northern International Medical College Journal Vol. 11 No. 1 July 2019, Page 427-431

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Published

2020-12-13

How to Cite

Rahman, M., Yasmeen, B. N., Jahan, N., Hoque, M. M., Halder, S. K., Halder, A., Nupur, N. R., Zerin, I. J., & Rini, F. A. (2020). Recent Trend of Bacteriological Profile and Drug Sensitivity Pattern of Neonatal Septicemia in A Tertiary Care Hospital in Bangladesh. Northern International Medical College Journal, 11(1), 427–431. https://doi.org/10.3329/nimcj.v11i1.50738

Issue

Vol. 11 No. 1 (2019)

Section

Original Articles