Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice

Authors

  • Zakia Sultana Sathi Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh
  • Ranjan Kumar Barman Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • M Anwarul Islam Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Md Mokhlesur Rahman Department of Anatomy, Islami Bank Medical College, Rajshahi, Bangladesh.
  • Md Anwar Habib Professor and Head, Department of Pharmacology, Rajshahi Medical College, Rajshahi-6000, Bangladesh

Keywords:

Toxicological studies, Brine shrimp and Mice

Abstract

The cytotoxic activity of the crude chloroform extract of Streptomyces species and a pure compound, 4-hydroxy nitrobenzene (ZS-3) isolated from chloroform extract was determined by brine shrimp lethality bioassay. The LD50 values of chloroform extract and compound (ZS-3) and ampicillin trihydrate were found to be 5.6, 6.6 and 5.0 μg ml-1, respectively. The acute toxicity of the compound (ZS-3) was also performed on Swiss albino mice. The median acute toxicity value (LD50) of ZS-3 was found to be 62 mg kg-1. Thus the isolated compound ZS-3 seems to be safe for therapeutic use.

TAJ 2010; 23(1): 6-9

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Published

2010-06-01

How to Cite

Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice. (2010). TAJ: Journal of Teachers Association, 23(1), 6-9. https://doi.org/10.3329/taj.v23i1.41122

Issue

Vol. 23 No. 1 (2010)

Section

Original Articles

How to Cite

Toxicological studies of a metabolite of Streptomyces species on Brine shrimp and Mice. (2010). TAJ: Journal of Teachers Association, 23(1), 6-9. https://doi.org/10.3329/taj.v23i1.41122