Comparison of Bronchodilator Response of Nebulized Salbutamol with Nebulized Salbutamol and Ipratropium Bromide in Patients with Acute Exacerbation of Advanced COPD

Authors

  • Md Aminul Hasan Assistant Professor, Department of Medicine, Shaheed Ziaur Rahman Medical College, Bogura, Bangladesh
  • Sonia Sheherin Radiotherapist, Department of Radiotherapy, Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh
  • Md Amzad Hossain Sardar Assistant Professor, Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh
  • Md Ruhul amin Medical Officer (Dialysis), Department of Nephrology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh
  • Md Ahsan Habib Assistant Professor, Department of Medicine, Shaheed Ziaur Rahman Medical College, Bogura, Bangladesh
  • Foysal Ahamed Assistant Professor, Department of Medicine, Mymensingh Medical College, Mymensingh, Bangladesh

DOI:

https://doi.org/10.3329/taj.v34i2.58556

Keywords:

Chronic Obstructive Pulmonary Disease, Salbutamol, Ipratropium Bromide

Abstract

Background: Patients admitted with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) are often prescribed ipratropium bromide in combination with a β2 agonist like salbutamol. Many studies have not shown any benefit in adding ipratropium bromide to salbutamol in acute exacerbations of COPD.

Objectives: To compare the response of combination therapy with two drugs vs. salbutamol alone in the treatment of acute exacerbations of COPD during hospital admission.

Materials and Methods: This cross-sectional comparative study was conducted among one hundred patients of acute exacerbation of COPD admitted in Rajshahi Medical College Hospital from January 2012 to July 2012. The patients were randomly allocated to receive either solution-1 (salbutamol 5mg alone) or solution-2 (salbutamol 5mg plus ipratropium bromide 500μgm) (all four times a day) on admission. All other treatment was prescribed at the discretion of the attending physician.FEV1 and FVC values at baseline, at 1 hour, on day 1, day three, and on discharge date were assessed. Patients completed a subjective symptom score at 1 hour, Day 1, Day 3, and on the discharge date. Length of stay in hospital was assessed.

Results: There was no significant difference in spirometric values at 1 hour, Day 1, Day 3, and during discharge between the two groups. The subjective improvement was similar with both treatments. There was no difference between the two groups in the mean (±SD) length of hospital stay (salbutamol 5.98(±1.67) days, salbutamol plus ipratropium bromide 5.8(±1.39) days; t=0.586, p>0.05).

Conclusion: The routine addition of nebulized ipratropium bromide to salbutamol appears to be of no benefit in the treatment of acute exacerbations of COPD.

TAJ 2021; 34: No-2: 56-63

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Published

2022-03-08

How to Cite

Hasan, M. A. ., Sheherin, S. ., Hossain Sardar, M. A. ., amin, M. R. ., Habib, M. A. ., & Ahamed, F. . (2022). Comparison of Bronchodilator Response of Nebulized Salbutamol with Nebulized Salbutamol and Ipratropium Bromide in Patients with Acute Exacerbation of Advanced COPD. TAJ: Journal of Teachers Association, 34(2), 56–63. https://doi.org/10.3329/taj.v34i2.58556

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Original Articles