Study on the effect of intracoronary Adenosine on the incidence of myonecrosis after elective percutaneous coronary intervention

Authors

  • Md Razib Ahsan Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md Abu Siddique Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • KMHS Sirajul Haque Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Syed Ali Ahsan Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md Khurshed Ahmed Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Md Mukhlesur Rahman Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/uhj.v4i2.2068

Keywords:

Adenosine, Creatine kinase MB fraction, Intracoronary, Myonecrosis, Percutaneous coronary intervention, Periprocedural

Abstract

Appearance of serum creatine kinase MB fraction (CK-MB), reflecting the periprocedural myonecrosis, after successful percutaneous coronary intervention (PCI) is associated with future cardiac adverse events. The intracoronary adenosine on the incidence of myonecrosis after elective PCI was assessed. In this prospective, case control study with a total of 60 patients, 30 cases pretreated with 50 micro grams bolus intracoronary adenosine before advancement of guidewire and 30 controls not pretreated was studied during elective PCI. Both groups received statin and loading dose of Clopidogrel. Myonecrosis was assessed by CK-MB level after PCI. Post procedural myonecrosis occurred in 16.7 % (n=5) in case group and 36.7 % (n=11) in control group (OR=1.818; 95% CI 0.841; P=0.080). The result is not statistically significant but shows that the incidence of myonecrosis was reduced from 36.7% to 16.7%. Intracoronary adenosine reduces the incidence of myonecrosis after elective PCI.

Keywords: Adenosine; Creatine kinase MB fraction; Intracoronary; Myonecrosis; Percutaneous coronary intervention; Periprocedural.  

doi:10.3329/uhj.v4i2.2068

University Heart Journal Vol. 4 No. 2 July 2008 p19-23

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Published

2009-02-02

How to Cite

Ahsan, M. R., Siddique, M. A., Haque, K. S., Ahsan, S. A., Ahmed, M. K., & Rahman, M. M. (2009). Study on the effect of intracoronary Adenosine on the incidence of myonecrosis after elective percutaneous coronary intervention. University Heart Journal, 4(2), 19–23. https://doi.org/10.3329/uhj.v4i2.2068

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Original Articles