N-Acetyl cysteine for prevention of contrast induced nephropathy

Authors

  • Anisul Awal Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Syed Ali Hasan Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Md Abu Siddique Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Bikash Subedi Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Jahanara Arzu Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Quazi Arif Ahmed Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • KMHS Sirajul Haque Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Md Ashraf Uddin Sultan Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka
  • Neena Islam Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka

DOI:

https://doi.org/10.3329/uhj.v5i2.4554

Keywords:

Anti Oxidant, contrast induced nephropathy

Abstract

The antioxidant N-acetyl Cysteine prevents contrast induced nephropathy in patients with impaired renal function who undergo coronary angiogeaphy. However its role in Bangladeshi population is not clear. This study was done determine whether oral acetylcysteine prevents contrast induced nephropathy in high risk patients.100 patients with mild to moderate renal insufficiency who are undergoing elective coronary angiography with or without intervention.50 patients were randomy assigned to receive oral N acetyl cysteine (600mg) twice daily on the day before and on the day of procedure. All patients received low osmolar contrast agent.10 (20%) control patients (no premedicationgroup) and none of acetyl cysteine (0%) group developed a more than 25% increase in serum creatinine level within 48 hours after contrast exposure. Acetyl cysteine prevents contrast induced nephropathy.

Keywords : Anti Oxidant; contrast induced nephropathy.

DOI: 10.3329/uhj.v5i2.4554

University Heart Journal Vol.5(2) July 2009 pp.56-58

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How to Cite

Awal, A., Hasan, S. A., Siddique, M. A., Subedi, B., Arzu, J., Ahmed, Q. A., Haque, K. S., Sultan, M. A. U., & Islam, N. (2010). N-Acetyl cysteine for prevention of contrast induced nephropathy. University Heart Journal, 5(2), 56–58. https://doi.org/10.3329/uhj.v5i2.4554

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Original Articles