Glycated Hemoglobin and short-term Prognosis in Patients with Acute Coronary Syndrome with Diabetes Mellitus: A Prospective Cohort Study

Authors

  • Fysal Faruq Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Syed Ali Ahsan Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Manzoor Mahmood Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • MRM Mandal Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Kamruzzaman Siddiki Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • ABM Golam Mostofa Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Md Azharul Islam Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • AKM Imtiaz Akand Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Sujoy Kumar Saha Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka
  • Tanjima Parvin Department of Cardiology, University Cardiac Center (UCC), Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka

DOI:

https://doi.org/10.3329/uhj.v17i2.54366

Keywords:

Glycated Hemoglobin, Coronary Syndrome, Cohort Study

Abstract

Background: Data on the association between glycemic control after percutaneous coronary intervention (PCI) and clinical outcomes are limited and controversial in diabetic patients. Objective:The aim of the study was to assess the impact of good glycaemic control on three months clinical outcomes in diabetic acute coronary syndrome (ACS) patients undergoing PCI, from a Bangladesh health service perspective. Materials and methods:This prospective cohort study which was conducted in UCC, BSMMU included 346 consecutive diabetic ACS patients who underwent PCI at department of cardiology, BSMMU. Diabetic patients were categorized into two groups based on their 3 months HbA1c levels: 169 (48.84%) diabetics with good glycaemic control (HbA1c < 7%) and 177 (51.16%) diabetics with poor glycaemic control (HbA1c ≥7%).The outcome was major adverse cardiovascular events (MACEs), defined as cardiac death, myocardial infarction (MI), definite stent thrombosis, target vessel revascularization and stroke. Results: At 3 months follow up, patients with poor glycaemic control had a significantly higher incidence of MI (6.2% vs 1.2%; p=0.021). No other adverse events were found significantly different between the groups at 3 months of PCI. Conclusion:Good glycaemic control to obtain HbA1c level <7% in diabetic ACS patients undergoing coronary artery stenting may be beneficial in reducing the risk of MACEs and improvement of clinical outcome after PCI during 3 months follow up.

University Heart Journal Vol. 17, No. 2, Jul 2021; 108-113

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Published

2021-06-28

How to Cite

Faruq, F., Ahsan, S. A., Mahmood, M., Mandal, M., Siddiki, K., Mostofa, A. G., Islam, M. A., Akand, A. I., Saha, S. K., & Parvin, T. (2021). Glycated Hemoglobin and short-term Prognosis in Patients with Acute Coronary Syndrome with Diabetes Mellitus: A Prospective Cohort Study. University Heart Journal, 17(2), 108–113. https://doi.org/10.3329/uhj.v17i2.54366

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Original Articles