Safety of Amiodarone in Ventricular Arrhythmia in Patients Admitted in Bangabandhu Sheikh Mujib Medical University

Authors

  • Sujoy Kumar Saha Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Manzoor Mahmood Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Dipal Krishna Adhikary Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Syed Ali Ahsan Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Chaudhury Meshkat Ahmed Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Md Harisul Hoque Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • MA Muqueet Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • MA Mustafa Zaman Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Md Abu Salim Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Md Fakhrul Islam Khaled Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Md Ariful Islam Joarder Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • MRM Mandal Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Mohammad Walidur Rahman National Institute of Cardiovascualr Disease (NICVD), Dhaka
  • Md Azharul Islam Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • AKM Imtiaz Akand Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Fysal Faruq Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka
  • Sajal Krishna Banerjee Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka

DOI:

https://doi.org/10.3329/uhj.v17i2.54369

Keywords:

Ventricular Arrhythmia, Amiodarone

Abstract

Background: Amiodarone is the most effective antiarrhythmic medications available today for the treatment of both atrial and ventricular arrhythmias. It is an iodinated benzofuran derivative with demonstrated efficacy against a range of cardiac arrhythmias, including atrial fibrillation, paroxysmal supraventricular tachycardias, and life-threatening ventricular arrhythmias. Objective: To evaluation the status of amiodarone with therapeutic dose in Bangladeshi population. Materials and Methods: The quasi experimental study was conducted in the Department of Cardiology in Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka during April, 2019 to March, 2020 Patients got admitted in the Department of Cardiology, BSMMU, consecutive patients who had been treated with amiodarone for arrhythmia were included in this study. Patients without an amiodarone prescription were assumed and patients who will not give informed written consent were excluded in this study. Results: The most common adverse event was bradycardia or conduction disturbance (9.0%) followed by 4(2.2%) thyroid toxicity, 3(1.7%) hepatic toxicity, 2(1.1%) eye toxicity and 1(0.6%) pulmonary toxicity. In multi variable logistic regression, bradycardia or conduction disturbance, amiodarone daily dose (≥300 mg) and duration of amiodarone (>4 month) was found to be significantly (p<0.05) associated with adverse effects of amiodarone. Conclusion: The most common adverse event was bradycardia or conduction disturbance followed by thyroid toxicity, hepatic toxicity, eye toxicity and pulmonary toxicity. Bradycardia or conduction disturbance, amiodarone daily dose (≥300 mg) and duration of amiodarone (>4 month) was found to be significantly associated with adverse effects of amiodarone.

University Heart Journal Vol. 17, No. 2, Jul 2021; 118-121

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Published

2021-06-28

How to Cite

Saha, S. K., Mahmood, M., Adhikary, D. K., Ahsan, S. A., Ahmed, C. M., Hoque, M. H., Muqueet, M., Zaman, M. M., Salim, M. A., Khaled, M. F. I., Joarder, M. A. I., Mandal, M., Rahman, M. W., Islam, M. A., Akand, A. I., Faruq, F., & Banerjee, S. K. (2021). Safety of Amiodarone in Ventricular Arrhythmia in Patients Admitted in Bangabandhu Sheikh Mujib Medical University. University Heart Journal, 17(2), 118–121. https://doi.org/10.3329/uhj.v17i2.54369

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Original Articles