Glycaemic status and insulin resistance in diabetic peripheral neuropathy

Authors

  • Taslima Akter Lecturer, Department of Physiology, Ibrahim Medical College, Dhaka
  • Qazi Shamima Akhter Professor & Head, Department of Physiology, Dhaka Medical College, Dhaka
  • Mezbahur Rahman Lecturer, Department of Forensic Medicine, Dhaka Medical College, Dhaka
  • Sabrina Fahmida Azim Assistant Professor, Kumudini Woman?s Medical College, Dhaka
  • Fouzia Farid Assistant Professor, Aichi Medical College, Dhaka

DOI:

https://doi.org/10.3329/jbsp.v11i2.30651

Keywords:

Diabetes mellitus, peripheral neuropathy, glycaemic status, insulin resistance

Abstract

Background: Complication of diabetes mellitus includes peripheral neuropathy which causes ischemic foot ulceration. Hyperglycemia and insulin resistance may accelerate the development of diabetic peripheral neuropathy.

Objective: To assess the glycaemic status and insulin resistance for development of peripheral neuropathy in type 2 diabetes mellitus.

Methods: This control case control study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2014 to June 2015. A total number of 150 Type 2 diabetic patients of both sexes were selected with age ranging 40 to 50 years. Among them, 75 patients with peripheral neuropathy were included in study group and 75 patients without peripheral neuropathy were control. For evaluation of glycaemic status, fasting serum glucose (FSG), Glycosylated hemoglobin (HbA1c) and to calculate insulin resistance by homeostatic model assessment for insulin resistance (HOMA-IR), fasting serum insulin (FSI), were estimated. For statistical analysis, unpaired Students t test was done.

Results: In this study, significant increase in FSG, HbA1c, FSI, HOMA-IR were found in diabetic subjects with peripheral neuropathy in comparison to control group.

Conclusion: From the study results, it is concluded that poor glycaemic control and greater insulin resistance may be associated with diabetic peripheral neuropathy.

Bangladesh Soc Physiol. 2016, December; 11(2): 54-58

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Author Biography

Taslima Akter, Lecturer, Department of Physiology, Ibrahim Medical College, Dhaka



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Published

2016-12-14

How to Cite

Akter, T., Akhter, Q. S., Rahman, M., Azim, S. F., & Farid, F. (2016). Glycaemic status and insulin resistance in diabetic peripheral neuropathy. Journal of Bangladesh Society of Physiologist, 11(2), 54–58. https://doi.org/10.3329/jbsp.v11i2.30651

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