Assessing Oral Mucosal Health: Secondary Bacterial Infections in Pediatric Patients with Type 1 Diabetes

Authors

  • Susant Mohanty Professor and Head, Department of Pediatrics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar 751003, Odisha, India. https://orcid.org/0009-0002-0269-7406
  • Subhajit Patra Under Graduate Trainee, Central Research Laboratory, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India https://orcid.org/0009-0006-7646-2107
  • Shakti Rath Associate Professor (Microbiology & Research), Central Research Laboratory, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha https://orcid.org/0000-0003-3249-9080
  • Rupsa Das Assistant Professor, Department of Oral Medicine and Radiology, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India https://orcid.org/0000-0003-2770-019X
  • Sourav Palai Research Associate, Central Research Laboratory, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India https://orcid.org/0000-0001-9106-631X
  • Debidatta Singhsamanta PhD Scholar (Biotechnology), Institute of Medical Sciences & Sum Hospital, Siksha O Anusandhan (Deemed to be) University, Bhubaneswar, Odisha, India https://orcid.org/0009-0008-3807-9961

DOI:

https://doi.org/10.3329/bjid.v12i1.77276

Keywords:

Type 1 diabetes, Pediatric patients, Oral Microniome, Salivary pH, Salivary flowrate

Abstract

Background: Juvenile diabetes or Type 1 Diabetes (T1D) mellitus is an autoimmune-mediated disease resulting in insulin deficiency, and it is the second most frequent disease in children. T1D also affects the oral health of a child.

Objectives: This current work was undertaken to characterise and compare the salivary microbiome of children with Type 1 Diabetes (T1D) and healthy controls while evaluating the influence of oral environmental factors such as DMFT index, salivary flow rate, and buffering capacity.

Methodology:  The study was a comparative cross-sectional study conducted at the Department of Pediatric and Preventive Dentistry and Central Research Laboratory, Institute of Dental Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, during the period from October 2023 to March 2024. A total of 20 children (10 healthy individuals, 10 with TID) were selected. Detailed case history and DMFT/DMFS index were recorded. The saliva sample was collected from all patients and was analysed for pH and flow rate. The samples were processed for microbiological evaluation using routine microbiological procedures, and the isolated bacteria were subjected to antibiotic sensitivity tests.

Results: Among 20 children, 10 (50%) had Type 1 Diabetes and 10 (50.0%) were healthy controls. The mean DMFT score was higher in the diabetic group (3.8 ± 1.03) compared to controls (2.8 ± 1.03), with a significant difference (p <0.05). Salivary flow rate, pH, and buffering capacity were lower in diabetic children (p < 0.01). The mean CFU count was higher in the diabetic group (20 ± 3.13) than in controls (11.4±2.46), showing significant variation (p < 0.05).

Conclusion: Children with Type 1 Diabetes showed altered salivary microbiota, reduced salivary flow rate, buffering capacity, and lower pH, resulting in higher DMFT scores and bacterial counts compared to healthy children.

Bangladesh Journal of Infectious Diseases, June 2025;12(1):141-150

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Published

2025-10-28

How to Cite

Mohanty, S., Patra, S., Rath, S., Das, R., Palai, S., & Singhsamanta, D. (2025). Assessing Oral Mucosal Health: Secondary Bacterial Infections in Pediatric Patients with Type 1 Diabetes. Bangladesh Journal of Infectious Diseases, 12(1), 141–150. https://doi.org/10.3329/bjid.v12i1.77276

Issue

Vol. 12 No. 1 (2025)

Section

Original Articles

License

Copyright (c) 2025 Susant Mohanty, Subhajit Patra, Shakti Rath, Rupsa Das, Sourav Palai, Debidatta Singhsamanta

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Copyright on any research article in the Bangladesh Journal of Infectious Diseases is retained by the author(s).

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Articles in the Bangladesh Journal of Infectious Diseases are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)

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