Relationship between peritumoral brain edema and Ki-67 antigen labelling index in intracranial meningiomas

Abstract

Introduction: The most common benign non-glial cerebral tumor in adults is a meningioma. In roughly 50–78%  of instances, peripheral brain edema (PTBE) is a common observation in meningioma, while it may not be  present in others. Although the Ki67 proliferation index may be able to predict the recurrence of tumors in  meningioma patients, there is a lack of conclusive evidence and relationships.  Objective: To enhance evaluation, correlate the Ki67 index of meningioma patients with peritumoral cerebral  edema.  Methods: This cross-sectional study involved 24 patients with meningioma (20 female, 4 male; mean age 39.95  ± 14.54 years). Pre-operative neuroimaging was used to evaluate all patients for the presence of cerebral  edema surrounding the lesion using brain MRI and histological confirmation. An immune-histochemical staining  known as the Ki-67 index was used to measure proliferative activity. The possibility of a relationship between  the levels of the Ki67 index and the existence of PTBE was investigated.  Result: WHO grade I tumors were identified in approximately twenty-three (95.8%) of the patients with PTBE,  mean age 39.95 with 14.54 SD and male to female ratio 5:1. Eight patients (33.3%) were classified as GR1  patients, one as GR2, and the majority of patients (15/62.5%) as GR0 patients. For G1, the greatest level is  represented by the mean value of the Ki-67 Index level, which is 7.00. When compared to gender, tumor  location, and meningioma type (p>0.05), the PTBE grading was statistically significant when it came to the  Ki-67 indices (p<0.05). Furthermore, the grading of peritumoral edema (PTBE) and the Ki-67 labelling index  value exhibited a substantial positive association, as indicated by the spearman correlation test, with a  significant p-value <0.05 and a coefficient value of r = 0.647.  Conclusion: Peritumoral brain edema (PTBE)-encircled meningioma had a strong correlation with Ki67 indices.

Bang. J Neurosurgery 2025; 14(2): 126-131