Histopathological pattern of malignancy in solitary thyroid nodule
Keywords:Solitary thyroid nodule, papillary carcinoma
Objective: To find out relative frequency and type of malignancy in solitary thyroid nodule (STN).
Methods: This cross sectional study done in the Department of Otolaryngology Head & Neck Surgery, Dhaka Medical College Hospital (DMCH), Dhaka and Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka during the period of July 2008 to June 2009. For this study, 118 patients who were admitted a case of solitary thyroid nodule for operation. Diagnosed the case by detailed history, clinical examination, investigations, analyzed data presented by various tables, graphs and figures. Total 118 patients were selected as per described criteria from the Department of otolaryngology and head-neck surgery DMCH & BSMMU, Dhaka from July 2008 to July 2009.
Results: In this study of 118 patients of STN, majority of the patients were within 21-40 years age group with female predominance. In thyroid malignancy male and female ratio was 1:1.75. Among 118 cases of solitary thyroid nodule 22 cases were malignant. Out of 22 malignant cases, 16(73%) were papillary carcinoma, 4(18%) were follicular carcinoma and 2(9%) were anaplastic carcinoma. Thyroid swelling was the common presentation in all cases (100%), some patients also presented with other symptoms like cervical lymphadenopathy in 6 (5.08%) cases, dysphagia 2(1.69%) cases and hoarseness of voice 1(0.85%) case. Study showed very significant difference (p <0.01) between papillary and follicular carcinoma, highly significant difference (p<0.001) between papillary and anaplastic carcinoma. So, papillary carcinoma was more common among all thyroid malignancies in patients with solitary thyroid nodule.
Conclusion: Significant proportion of solitary thyroid nodule (18.65%) was malignant. So, careful assessment of thyroid nodule is important for early diagnosis.
Bangladesh J Otorhinolaryngol 2012; 18(1): 5-10
How to Cite
Manuscripts submitted for publication in the Bangladesh Journal of Otorhinolaryngology must not have been previously submitted or published. Accepted papers become the permanent property of the Bangladesh Journal of Otorhinolaryngology. By submitting a manuscript, the authors(s) agree that copyrights for their articles are automatically transferred to Bangladesh Journal of Otorhinolaryngology, if and when the articles are accepted for publication.
The use, in this journal, of registered trade names, trade marks, etc. without special acknowledgement does not imply that such names, as defined by the relevant protection laws, be regarded as unprotected, and, thus, free for general use.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).