One pot synthesis of Biginelli 3,4-dihydro-1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines

Authors

  • Md E Halim Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • K Akhter Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • SM Ahmed Department of Chemistry, American International University-Bangladesh, 408/1 Kuratoli, Khilkhet, Dhaka-1229, Bangladesh
  • Md Al Amin Hossain Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh
  • UKR Romman Department of Chemistry, University of Dhaka, Dhaka-1000, Bangladesh

DOI:

https://doi.org/10.3329/bjsir.v55i3.49390

Keywords:

Substituted benzaldehydes; Ethyl acetoacetate; Acetylacetone; Zinc chloride; Biginelli reaction

Abstract

A simple and practical route for the Biginelli cyclocondensation reaction using anhydrous ZnCl2 as a catalyst in n-heptane-toluene medium by reaction of substituted benzaldehydes,1a-d (1a=2-ClC6H4-, 1b=2-BrC6H4- and 1c=4-ClC6H4-,1d=2-H3CC6H4-) with 1, 3-dicarbonyl compounds, 2a-b (2a= ethyl acetoacetate and 2b= acetylacetone) and urea or thiourea, 3a-b to give the corresponding Biginelli 3,4-dihydro- 1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines, 4a-d. The structures of the compounds 4a-d were confirmed by their ultraviolet, infrared, 1H NMR, 13C NMR spectra and elemental analyses.

Bangladesh J. Sci. Ind. Res.55(3), 173-180, 2020

Downloads

Download data is not yet available.
Abstract
30
PDF
39

Downloads

Published

2020-09-24

How to Cite

Halim, M. E., Akhter, K., Ahmed, S., Hossain, M. A. A., & Romman, U. (2020). One pot synthesis of Biginelli 3,4-dihydro-1H-pyrimidin-2-ones and 1,2,3,4-tetrahydro pyrimidines. Bangladesh Journal of Scientific and Industrial Research, 55(3), 173–180. https://doi.org/10.3329/bjsir.v55i3.49390

Issue

Vol. 55 No. 3 (2020)

Section

Articles

License

Bangladesh Council of Scientific and Industrial Research (BCSIR) holds the copyright to all contents published in Bangladesh Journal of Scientific and Industrial Research (BJSIR). A copyright transfer form should be signed by the author(s) and be returned to BJSIR.

The entire contents of the BJSIR are protected under Bangladesh Council of Scientific and Industrial Research (BCSIR) copyrights.

Creative Commons Licence
BJSIR is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC) Creative Commons Attribution-NonCommercial 4.0 International License which allows others remix, tweak, and build upon the articles non-commercially, and although their new works must also acknowledge and be non-commercial, they don’t have to license their derivative works on the same terms.