Newcastle disease vaccination regimen comprising both Lentogenic and Mesogenic strains is more effective than Lentogenic strain only

Authors

  • LR Barman Mirpur Central Poultry Farm, Department of Livestock Services, Dhaka
  • MN Islam Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh
  • MF Flensburg The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C
  • A Permin The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C
  • SL Petersen The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C
  • MR Islam Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh

DOI:

https://doi.org/10.3329/bvet.v27i1.5908

Keywords:

Newcastle disease vaccination

Abstract

Two vaccination regimens against Newcastle disease were compared. A total of 180
crossbred (RIR × Fayoumi) day-old chicks were obtained from the government Poultry
Farm. At three days of age, 10 birds were randomly selected and killed to obtain blood
samples for serum collection. The remaining 170 birds were divided into three groups.
Group A, (55) received a locally produced live lentogenic Newcastle disease virus (NDV)
vaccine called “Baby Chick Ranikhet Disease Vaccine” (BCRDV) intraocularly at three
and 28 days of age followed by a live mesogenic NDV vaccine namely “Ranikhet Disease
Vaccine” (RDV) intramuscularly at 60 days of age. Group B, (55) was vaccinated with an
imported live lentogenic commercial vaccine intraocularly at three, 28 and 60 days of age.
Group C, (60) served as unvaccinated control. Further blood samples were collected on
day 28, 60 and 74 from all groups. All the sera were tested for haemagglutination
inhibition (HI) antibody titre to NDV. At 75 days of age, 30 birds from each of the two
vaccinated groups and 32 birds from the unvaccinated group were challenged with a
velogenic viscerotropic field isolate of NDV. The chicks had a high level of maternal HI
antibodies at three days of age with a geometric mean titre (GMT) of log2 4.8, but that
gradually declined in the unvaccinated group. Following vaccination there was no
remarkable rise in the antibody titre at 28 and 60 days of age (GMT>log2 3.5), but at 74
days of age, the GMT of HI antibody in Group A (log2 5.9) was significantly higher than
that in the Group B (log2 4.1). Following challenge, 100% morbidity and 65.6% mortality
were observed in the unvaccinated group. Among the vaccinated groups, only 16.7%
morbidity and no mortality were noticed in Group A but 43.3% morbidity and 10%
mortality were observed in Group B. It is suggested that a vaccination programme based
on lentogenic priming and mesogenic booster gave better protection against velogenic
viscerotropic NDV challenge than that based on lentogenic vaccine only.
(Bangl. vet. 2010. Vol. 27, No. 1, 1 – 7)
DOI: 10.3329/bvet.v27i1.5908

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How to Cite

Barman, L., Islam, M., Flensburg, M., Permin, A., Petersen, S., & Islam, M. (2010). Newcastle disease vaccination regimen comprising both Lentogenic and Mesogenic strains is more effective than Lentogenic strain only. Bangladesh Veterinarian, 27(1), 1–7. https://doi.org/10.3329/bvet.v27i1.5908

Issue

Vol. 27 No. 1 (2010)

Section

Articles