Synthesis, Characterization and Biomedical Studies of Cadmium(II) Complexes of an N-Pendent Polyazamacrocyclic Ligand

Authors

  • Sidratul Muntaha Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Saswata Rabi Department of Chemistry, Chittagong University of Engineering and Technology, Chittagong-4349, Bangladesh
  • Avijit Chakraborty Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Pradip Paul Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Foni Bushon Biswas Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Debashis Palit Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh
  • Tapashi Ghosh Roy Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

Keywords:

Macrocyclic ligands, ; N-pendent derivative, Cadmium(II) complexes, Spectroscopic characterization, Antibacterial activity

Abstract

An isomeric octamethyl-substituted tetraazamacrocycle, LB (a C-chiral isomer of 3,10-C-meso-Me8[14]ane), was reacted with methyl iodide in a 1:4 molar ratio under reflux in methanol to yield a white N-pendent derivative ligand, LBZ. Complexation of LBZ with cadmium(II) perchlorate produced a six-coordinate diperchlorato octahedral complex, [CdLBZ(ClO4)2], and a five-coordinate square-pyramidal complex, [CdLBZ(ClO4)]. The diperchlorato complex underwent axial substitution reactions with NCS-, NO3-, NO2-, Cl-, Br- and I-, forming a series of six-coordinate octahedral complexes: [CdLBZ(NCS)2], [CdLBZ(NO3)(ClO4)], [CdLBZ(NO2)(ClO4)], [CdLBZCl(ClO4)], [CdLBZBr2] and [CdLBZI2]. All newly synthesized compounds were characterized using elemental analysis, IR, UV–visible and 1H-NMR spectroscopy, molar conductivity and magnetic susceptibility measurements. The antibacterial activities of LBZ and its cadmium(II) complexes were evaluated against selected phytopathogenic bacteria. While the free ligands were inactive, most cadmium(II) complexes exhibited significant antibacterial activity, particularly against Bacillus cereus.

The Chittagong Univ. J. Sci. 46(1): 164-177, 2025

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Author Biographies

Foni Bushon Biswas, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

Associate Professor

Debashis Palit, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

Professor

Tapashi Ghosh Roy, Department of Chemistry, University of Chittagong, Chittagong-4331, Bangladesh

Professor

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Published

2026-08-10

Issue

Vol. 46 No. 1 (2025)

Section

Articles

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Copyright (c) 2025 Sidratul Muntaha, Saswata Rabi, Avijit Chakraborty, Pradip Paul, Foni Bushon Biswas, Debashis Palit, Tapashi Ghosh Roy

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How to Cite

Muntaha, S., Rabi, S., Chakraborty, A., Paul, P., Biswas, F. B., Palit, D., & Roy, T. G. (2026). Synthesis, Characterization and Biomedical Studies of Cadmium(II) Complexes of an N-Pendent Polyazamacrocyclic Ligand. The Chittagong University Journal of Science, 46(1), 164-177. https://doi.org/10.3329/cujs.v46i1.90725