Forensic microsatellite TH01 and malaria predisposition

Authors

  • Shafiul Alam Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka
  • Ahmad Ferdous Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka
  • Md Eunus Ali Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka
  • Asma Ahmed Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka
  • Apala Farhat Naved National Forensic DNA Profiling Laboratory, Dhaka Medical College, Dhaka
  • Sharif Akhteruzzaman Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka

DOI:

https://doi.org/10.3329/dujbs.v20i1.8831

Keywords:

Microsatellites, Allele, Genotype, Locus, Malaria

Abstract

It is hypothesized that microsatellite locus TH01, which is located in close proximity to beta-globin gene and immune regulatory region in human, plays a role in malaria predisposition. In this study, authors verified the association of microsatelite allele (AATG repeat unit) at TH01 locus with malaria infection. The study provided significant evidence that allele-9 at this locus in P. falciparum infected individual illustrate the genetic predisposition towards the disease. Moreover, the predominance of allele-9 at TH01 in the individuals inhabiting malaria endemic area suggests that genetic predisposition towards malaria is an archaic phenomenon.

Key words: Microsatellites; Allele; Genotype; Locus, Malaria

DOI: http://dx.doi.org/10.3329/dujbs.v20i1.8831

Dhaka Univ. J. Biol. Sci. 20(1): 1-6, 2011 (January)

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How to Cite

Alam, S., Ferdous, A., Ali, M. E., Ahmed, A., Naved, A. F., & Akhteruzzaman, S. (2011). Forensic microsatellite TH01 and malaria predisposition. Dhaka University Journal of Biological Sciences, 20(1), 1–6. https://doi.org/10.3329/dujbs.v20i1.8831

Issue

Vol. 20 No. 1 (2011)

Section

Articles