Wound healing activity of Cleome rutidosperma DC. roots

Authors

  • Sumanta Mondal GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar, Visakhapatnam-530 045, Andhra Pradesh
  • Padilam Suresh GITAM Institute of Pharmacy, GITAM University, Gandhi Nagar, Visakhapatnam-530 045, Andhra Pradesh

DOI:

https://doi.org/10.3329/icpj.v1i6.10536

Keywords:

Cleome rutidosperma DC, wound healing activity, nitrofurazone, excision wound, incision wound

Abstract

The petroleum ether, chloroform, methanol and aqueous extracts of Cleome rutidosperma DC (Family: Capparidaceae) roots were evaluated for their wound healing activities in rats using excision and incision wound models respective-ly. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation and wound breaking strength. Nitrofurazone (0.2% w/w) in simple ointment I.P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of C. rutidosperma showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plant also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of C. rutidosperma roots for wound healing activity as claimed in the folklore literature.

DOI: http://dx.doi.org/10.3329/icpj.v1i6.10536

International Current Pharmaceutical Journal 2012, 1(6): 151-154

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Published

2012-05-06

How to Cite

Mondal, S., & Suresh, P. (2012). Wound healing activity of Cleome rutidosperma DC. roots. International Current Pharmaceutical Journal, 1(6), 151–154. https://doi.org/10.3329/icpj.v1i6.10536

Issue

Vol. 1 No. 6 (2012)

Section

Original Articles

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