Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers

Authors

  • P D Thahera Professor Department of Pharmaceutics M.M.U. College of Pharmacy Ramanagaram, Bangalore
  • Mr Ashok Department of Pharmaceutics M.M.U. College of Pharmacy Ramanagaram, Bangalore
  • K Latha G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad-500 028
  • T Shailaja G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad-500 028
  • S Nyamathulla Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur,
  • M U Uhumwangho Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin

DOI:

https://doi.org/10.3329/icpj.v1i7.10809

Keywords:

Gastrointestinal, Norfloxacin, Guar gum, Sodium CMC, HPMC 15KM, GRFDDS

Abstract

Gastric retentive floating drug delivery system (GFDDS) is enabled the prolonged continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improves the bioavailability of medications with narrow absorption window. The design of the delivery system is based on the controlled release formulation with floating and swelling features in order to prolong the gastric retention time of the drug delivery systems. In the present study norfloxacin as candidate, guar gum, sodium CMC, HPMC15 KM is studied along with other excipients like PVP K30 (binder), sodium bicarbonate microcrystalline cellulose were used in different concentrations to get the desired controlled release profile over a period of 12 hrs. All the formulations were evaluated for buoyancy lag time, duration of buoyancy, dimensional stability, drug content and in vitro drug release profile. Based on the in vitro studies carried out for the optimized formulation by dissolution the performance of the developed formulation promises to be efficient in controlling the drug release rate with the guar gum, a natural polymer.

DOI: http://dx.doi.org/10.3329/icpj.v1i7.10809

International Current Pharmaceutical Journal 2012, 1(7): 155-164

 

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Published

2012-06-03

How to Cite

Thahera, P. D., Ashok, M., Latha, K., Shailaja, T., Nyamathulla, S., & Uhumwangho, M. U. (2012). Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers. International Current Pharmaceutical Journal, 1(7), 155–164. https://doi.org/10.3329/icpj.v1i7.10809

Issue

Vol. 1 No. 7 (2012)

Section

Original Articles

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