Design and evaluation of rectal drug delivery systems of non-steroidal anti-inflammatory drug

Authors

  • P V Swamy Sr. Professor, Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram 534 202, West Godavari, Andhra Pradesh
  • Mohammed Younus Ali Principal, KCT College of Pharmacy P. Box No.-104, Qamar Ul Islam Colony Gulbarga-585104, Karnataka
  • Y Anand Kumar V.L College of Pharmacy, Raichur
  • K Prasad Sr. Professor, Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram 534 202, West Godavari, Andhra Pradesh
  • N Srinivaslu V.L College of Pharmacy, Raichur

DOI:

https://doi.org/10.3329/icpj.v1i7.10810

Keywords:

Suppositories, diffusion, hydrogenated vegetable oil, beeswax, zero order, stability studies

Abstract

The aim of the present study was to design and evaluate the suppositories of aceclofenac a non-steroidal anti inflammatory drug (NSAID). Aceclofenac, rectal suppositories were developed by employing various hydrophilic and hydrophobic polymeric bases like gelatin, PEG-400 and hydrogenated vegetable oil using propylene glycol as plasticizer and beeswax as hardening agent. The in-vitro release rate data was evaluated statistically and was found that from all the formulations the drug release is by diffusion mechanism (r = 0.9547 to 0.9967) according to Higuchis equation. All the prepared formulations have shown zero-order release kinetics except those prepared by utilizing 15% and 20 % of PEG-400. The formulation prepared using 7.5% beeswax in hydrogenated vegetable oil has displayed zero-order drug release (r = 0.9927) and has released 99.18% of the aceclofenac within 4h, hence, this formulation is considered as a promising formulation. The stability study on the promising formulation was conducted over a period of 6 months and found that there are no significant changes in the drug content and in-vitro drug release rate (p<0.05). The result suggests that the suppositories can be prepared by employing hydrophilic and hydrophobic polymers.

DOI: http://dx.doi.org/10.3329/icpj.v1i7.10810

International Current Pharmaceutical Journal 2012, 1(7): 165-170

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Published

2012-06-03

How to Cite

Swamy, P. V., Ali, M. Y., Kumar, Y. A., Prasad, K., & Srinivaslu, N. (2012). Design and evaluation of rectal drug delivery systems of non-steroidal anti-inflammatory drug. International Current Pharmaceutical Journal, 1(7), 165–170. https://doi.org/10.3329/icpj.v1i7.10810

Issue

Vol. 1 No. 7 (2012)

Section

Original Articles

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